Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPKAPK2 | P49137 | 3/20 | 0.53 |
| ▸ | EGFR | P00533 | 1/20 | 0.41 |
| ▸ | ABCG2 | Q9UNQ0 | 2/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 6/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.40 |
| ▸ | MEN1 | O00255 | 4/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.40 |
| ▸ | PDE5A | O76074 | 2/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.40 |
| ▸ | CYP2B6 | P20813 | 1/20 | 0.40 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.40 |
| ▸ | ADRA2A | P08913 | 3/20 | 0.38 |
| ▸ | ADRA2B | P18089 | 3/20 | 0.38 |
| ▸ | ADRA2C | P18825 | 3/20 | 0.38 |
| ▸ | ADRA1D | P25100 | 3/20 | 0.38 |
| ▸ | ADRA1A | P35348 | 3/20 | 0.38 |
| ▸ | ADRA1B | P35368 | 3/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6237305 | 0.81 | MAPKAPK2 (0.62) | MAPKAPK2HTR2A | |
| SCHEMBL6236968 | 0.80 | MAPKAPK2 (0.81) | MAPKAPK2ABCG2CYP2D6KMT2ACYP1A2 | |
| SCHEMBL6238198 | 0.72 | MAPKAPK2 (0.63) | MAPKAPK2HSD17B10KDM4ELMNAHPGD | |
| SCHEMBL1658785 | 0.69 | MAPKAPK2 (1.00) | MAPKAPK2ABCG2KMT2AHTR2BALDH1A1 | |
| SCHEMBL12660648 | 0.68 | MAPKAPK2 (0.55) | MAPKAPK2EGFRABCG2ADRA1DADRA1A | |
| SCHEMBL6235510 | 0.68 | MAPKAPK2 (0.81) | MAPKAPK2ABCG2CYP2D6KMT2ACYP1A2 | |
| SCHEMBL10484426 | 0.68 | CYP19A1 (0.52) | MAPKAPK2EGFRABCG2CYP2D6CYP3A4 | |
| Hydrochloric Acid SCHEMBL31036471 | 0.68 | KDM4E (0.68) | CYP2D6MEN1KMT2ACYP1A2PDE5A | |
| SCHEMBL16433469 | 0.68 | SIRT1 (0.60) | CYP2D6MEN1KMT2AKCNH2KDM4E | |
| SCHEMBL9687220 | 0.67 | MAPKAPK2 (0.50) | MAPKAPK2MEN1KMT2AKDM4ELMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0273321-B1 | 7-BROMO-BETA-CARBOLINE COMPOUND AND METHOD FOR PRODUCING SAME | Kawaken Fine Chemicals Co., Ltd. (JP) | 1992-04-22 | — | — | EP | disclosed |