Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKT1 | P31749 | 6/20 | 0.52 |
| ▸ | PIK3CD | O00329 | 5/20 | 0.52 |
| ▸ | PIK3CB | P42338 | 5/20 | 0.52 |
| ▸ | PIK3CG | P48736 | 3/20 | 0.52 |
| ▸ | PIK3CA | P42336 | 3/20 | 0.52 |
| ▸ | WNT3A | P56704 | 1/20 | 0.51 |
| ▸ | USP2 | O75604 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.48 |
| ▸ | LMNA | P02545 | 2/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL970919 | 0.92 | WNT3A (0.52) | AKT1PIK3CDPIK3CBPIK3CGPIK3CA | |
| SCHEMBL30795276 | 0.92 | WNT3A (0.52) | AKT1PIK3CDPIK3CBPIK3CGPIK3CA | |
| SCHEMBL971761 | 0.91 | GAA (0.56) | AKT1PIK3CDPIK3CBPIK3CGPIK3CA | |
| SCHEMBL973883 | 0.90 | PIK3CD (0.54) | AKT1PIK3CDPIK3CBPIK3CGPIK3CA | |
| SCHEMBL30824698 | 0.90 | PIK3CD (0.54) | AKT1PIK3CDPIK3CBPIK3CGPIK3CA | |
| SCHEMBL973838 | 0.89 | WNT3A (0.50) | AKT1PIK3CDPIK3CBPIK3CGPIK3CA | |
| SCHEMBL971254 | 0.89 | SMN1; SMN2 (0.55) | AKT1PIK3CDPIK3CBPIK3CAWNT3A | |
| SCHEMBL30795411 | 0.89 | SMN1; SMN2 (0.55) | AKT1PIK3CDPIK3CBPIK3CAWNT3A | |
| SCHEMBL30794865 | 0.89 | WNT3A (0.50) | AKT1PIK3CDPIK3CBPIK3CGPIK3CA | |
| SCHEMBL971267 | 0.89 | AKT1 (0.52) | AKT1PIK3CDPIK3CBPIK3CGPIK3CA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2298766-B1 | Pharmaceutical formulations comrpising a substituted pyridine derivative | LUNDBECK & CO AS H (DK) | 2013-09-18 | — | — | EP | claimed |
| EP-2298766-A1 | Substituted pyridine derivatives | H. Lundbeck A/S (DK) | 2011-03-23 | — | — | EP | claimed |
| US-7812020-B2 | Substituted pyridine derivatives | H. LUNDBECK A/S (DK) | 2010-10-12 | — | — | US | claimed |
| EP-2298766-B1 | Pharmaceutical formulations comrpising a substituted pyridine derivative | LUNDBECK & CO AS H (DK) | 2013-09-18 | — | — | EP | disclosed |
| US-8299071-B2 | Substituted pyridine derivatives | H. LUNDBECK A/S (DK) | 2012-10-30 | — | — | US | disclosed |
| EP-2298766-A1 | Substituted pyridine derivatives | H. Lundbeck A/S (DK) | 2011-03-23 | — | — | EP | disclosed |
| US-20110003811-A1 | SUBSITUTED PYRIDINE DERIVATIVES | H. LUNDBECK A/S (DK) | 2011-01-06 | — | — | US | disclosed |
| US-7812020-B2 | Substituted pyridine derivatives | H. LUNDBECK A/S (DK) | 2010-10-12 | — | — | US | disclosed |
| US-20080318953-A1 | Substituted Pyridine Derivatives | H. LUNDBECK A/S (DK) | 2008-12-25 | — | — | US | disclosed |
| EP-1861394-A1 | SUBSTITUTED PYRIDINE DERIVATIVES | H.Lundbeck A/S (DK) | 2007-12-05 | — | — | EP | disclosed |
| WO-2006092143-A1 | SUBSTITUTED PYRIDINE DERIVATIVES | H. LUNDBECK A/S (DK) | 2006-09-08 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080318953-A1 | Substituted Pyridine Derivatives | KCNQ2, KCNQ1, KCNQ5 | AKT1 4427/4885PIK3CD 1381/4885PIK3CB 1169/4885 |
| US-20110003811-A1 | SUBSITUTED PYRIDINE DERIVATIVES | KCNQ2, KCNQ1, KCNQ5 | AKT1 3936/4885PIK3CD 1723/4885PIK3CB 1666/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.