Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXFP1 | Q9HBX9 | 4/20 | 0.56 |
| ▸ | MAPT | P10636 | 6/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.52 |
| ▸ | LMNA | P02545 | 3/20 | 0.52 |
| ▸ | NPC1 | O15118 | 1/20 | 0.52 |
| ▸ | HTT | P42858 | 4/20 | 0.50 |
| ▸ | TP53 | P04637 | 1/20 | 0.50 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.49 |
| ▸ | BRAF | P15056 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 2/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | RAB9A | P51151 | 1/20 | 0.49 |
| ▸ | ATM | Q13315 | 1/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10870450 | 0.89 | KDM4E (0.48) | RXFP1MAPTNPC1TP53MCHR1 | |
| SCHEMBL9686123 | 0.86 | RXFP1 (0.59) | RXFP1MAPTSMN1; SMN2LMNANPC1 | |
| SCHEMBL9702721 | 0.80 | NPC1 (0.55) | MAPTSMN1; SMN2NPC1TP53MEN1 | |
| SCHEMBL9701811 | 0.79 | MEN1 (0.50) | MAPTSMN1; SMN2LMNANPC1HTT | |
| SCHEMBL7607258 | 0.75 | MAPT (0.62) | MAPTSMN1; SMN2LMNAHTTTP53 | |
| SCHEMBL30499684 | 0.75 | MAPT (0.62) | MAPTSMN1; SMN2LMNAHTTTP53 | |
| SCHEMBL7603216 | 0.74 | KDR (0.66) | RXFP1MAPTSMN1; SMN2LMNAHTT | |
| SCHEMBL30499683 | 0.74 | KDR (0.66) | RXFP1MAPTSMN1; SMN2LMNAHTT | |
| SCHEMBL10869152 | 0.74 | KDM4E (0.58) | RXFP1MAPTNPC1TP53BRAF | |
| SCHEMBL15529040 | 0.74 | RXFP1 (0.69) | RXFP1MAPTCYP1A2CYP3A4CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5166180-A | Administering diphenyl substituted (thio)carbonyl(thio)urea derivatives | DUPHAR INTERNATIONAL RESEARCH B.V. (NL) | 1992-11-24 | — | — | US | disclosed |
| EP-0324521-A2 | Method of treating haematologic diseases and pharmaceutical compositions to be used therefor | DUPHAR INTERNATIONAL RESEARCH B.V (NL) | 1989-07-19 | — | — | EP | disclosed |