Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 4/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | GLA | P06280 | 3/20 | 0.44 |
| ▸ | GAA | P10253 | 3/20 | 0.44 |
| ▸ | LMNA | P02545 | 3/20 | 0.44 |
| ▸ | HPGD | P15428 | 2/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.44 |
| ▸ | NPC1 | O15118 | 2/20 | 0.44 |
| ▸ | RAB9A | P51151 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | POLB | P06746 | 2/20 | 0.44 |
| ▸ | HTT | P42858 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | RECQL | P46063 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9693221 | 1.00 | ACHE (0.48) | ACHEKDM4EALDH1A1GLAGAA | |
| SCHEMBL9686653 | 1.00 | ACHE (0.48) | ACHEKDM4EALDH1A1GLAGAA | |
| SCHEMBL9686907 | 1.00 | ACHE (0.48) | ACHEKDM4EALDH1A1GLAGAA | |
| SCHEMBL2288150 | 0.99 | KDM4E (0.48) | ACHEKDM4EALDH1A1GLAGAA | |
| SCHEMBL9693584 | 0.96 | ACHE (0.47) | ACHEKDM4EALDH1A1GLAGAA | |
| SCHEMBL7912951 | 0.87 | ACHE (0.49) | ACHEKDM4EALDH1A1GLAGAA | |
| SCHEMBL9687387 | 0.85 | ACHE (0.50) | ACHEKDM4EALDH1A1GLAGAA | |
| SCHEMBL9693236 | 0.85 | ACHE (0.50) | ACHEKDM4EALDH1A1GLAGAA | |
| SCHEMBL9686312 | 0.85 | ACHE (0.50) | ACHEKDM4EALDH1A1GLAGAA | |
| SCHEMBL9685361 | 0.85 | ACHE (0.50) | ACHEKDM4EALDH1A1GLAGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0270494-B1 | Certain cycloalka- [b]-pyrazolo-[3,4-d]-pyridin-3-one derivatives | CIBA-GEIGY AG (CH) | 1992-08-19 | — | — | EP | disclosed |
| US-4826854-A | Certain cycloalka-(b)-pyrazolo(3,4-d)-pyridin-3-one derivatives | CIBA-GEIGY CORPORATION (US) | 1989-05-02 | — | — | US | disclosed |
| EP-0270494-A2 | Certain cycloalka- [b]-pyrazolo-[3,4-d]-pyridin-3-one derivatives | CIBA-GEIGY AG (CH) | 1988-06-08 | — | — | EP | disclosed |