Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.60 |
| ▸ | MAPT | P10636 | 11/20 | 0.56 |
| ▸ | THRB | P10828 | 1/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.55 |
| ▸ | MEN1 | O00255 | 2/20 | 0.55 |
| ▸ | PKM | P14618 | 1/20 | 0.55 |
| ▸ | HTT | P42858 | 2/20 | 0.54 |
| ▸ | LMNA | P02545 | 3/20 | 0.53 |
| ▸ | GAA | P10253 | 2/20 | 0.53 |
| ▸ | STAT3 | P40763 | 1/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.51 |
| ▸ | SERPINE1 | P05121 | 2/20 | 0.50 |
| ▸ | NPC1 | O15118 | 1/20 | 0.50 |
| ▸ | RAB9A | P51151 | 1/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.49 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.49 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9687209 | 0.85 | MAPT (0.53) | SMN1; SMN2MAPTKMT2AMEN1PKM | |
| SCHEMBL2879386 | 0.84 | MAPT (0.60) | MAPTKMT2AMEN1PKMHTT | |
| SCHEMBL5361493 | 0.83 | MAPT (0.70) | SMN1; SMN2MAPTTHRBKMT2AMEN1 | |
| SCHEMBL13331971 | 0.81 | GAA (0.55) | SMN1; SMN2MAPTTHRBKMT2AMEN1 | |
| SCHEMBL7335661 | 0.81 | MAPT (0.63) | SMN1; SMN2MAPTKMT2AMEN1PKM | |
| SCHEMBL13528776 | 0.81 | MAPT (0.65) | SMN1; SMN2MAPTKMT2AMEN1PKM | |
| SCHEMBL16713330 | 0.81 | MAPT (0.56) | SMN1; SMN2MAPTKMT2AMEN1PKM | |
| SCHEMBL12004226 | 0.81 | MAPT (0.56) | MAPTKMT2AMEN1PKMLMNA | |
| SCHEMBL4537985 | 0.81 | MAPT (0.62) | MAPTKMT2AMEN1PKMLMNA | |
| SCHEMBL7170328 | 0.81 | MAPT (0.57) | SMN1; SMN2MAPTTHRBKMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5171748-A | For hypertension, cardiovascular disorders | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1992-12-15 | — | — | US | disclosed |