Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Oxalic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP17A1 | P05093 | 4/20 | 0.52 |
| ▸ | CYP24A1 | Q07973 | 8/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.36 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.36 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.36 |
| ▸ | FAAH | O00519 | 1/20 | 0.36 |
| ▸ | MGLL | Q99685 | 1/20 | 0.36 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9687706 | 0.87 | CYP17A1 (0.53) | CYP17A1CYP11B1CYP11B2FAAHMGLL | |
| SCHEMBL10464807 | 0.82 | CYP17A1 (0.51) | CYP17A1CYP11B1CYP11B2 | |
| SCHEMBL9688917 | 0.78 | CYP17A1 (0.54) | CYP17A1CYP24A1CYP19A1 | |
| SCHEMBL9688727 | 0.74 | CYP17A1 (0.40) | CYP17A1CYP24A1CYP11B1CYP11B2CYP19A1 | |
| SCHEMBL9689763 | 0.73 | CYP17A1 (0.48) | CYP17A1CYP11B1CYP11B2CYP19A1 | |
| SCHEMBL9910964 | 0.73 | CYP17A1 (0.84) | CYP17A1CYP24A1CYP11B1CYP11B2CYP19A1 | |
| SCHEMBL10466649 | 0.71 | CYP17A1 (0.55) | CYP17A1CYP11B1CYP11B2CYP19A1 | |
| Citric Acid SCHEMBL9688655 | 0.71 | CYP17A1 (0.41) | CYP17A1CYP24A1KDM4ETBXA2RCYP11B1 | |
| Maleic Acid SCHEMBL9688630 | 0.69 | CYP17A1 (0.42) | CYP17A1CYP24A1FAAHCYP19A1 | |
| Fumaric Acid SCHEMBL10464858 | 0.69 | CYP17A1 (0.42) | CYP17A1CYP24A1FAAHCYP19A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0298921-B1 | 1,2-BENZISOXAZOLES AND 1,2-BENZISOTHIAZOLES | CIBA-GEIGY AG (CH) | 1992-12-23 | — | — | EP | disclosed |
| US-4957931-A | ANTICONVULSANTS, TREATMENT OF EPILEPSY | CIBA-GEIGY CORPORATION (US) | 1990-09-18 | — | — | US | disclosed |
| US-4859691-A | Certain 1,2-benzisoxazole derivatives | CIBA-GEIGY CORPORATION (US) | 1989-08-22 | — | — | US | disclosed |
| EP-0298921-A1 | 1,2-Benzisoxazoles and 1,2-benzisothiazoles | CIBA-GEIGY AG (CH) | 1989-01-11 | — | — | EP | disclosed |