Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPRT1 | P00492 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.37 |
| ▸ | TSHR | P16473 | 2/20 | 0.37 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | HPGD | P15428 | 5/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.33 |
| ▸ | CYP1A1 | P04798 | 4/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 4/20 | 0.33 |
| ▸ | CYP1B1 | Q16678 | 4/20 | 0.33 |
| ▸ | MAPT | P10636 | 4/20 | 0.33 |
| ▸ | POLB | P06746 | 2/20 | 0.33 |
| ▸ | HTT | P42858 | 2/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | PDE5A | O76074 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20870711 | 0.75 | SMN1; SMN2 (0.41) | SMN1; SMN2LMNA | |
| SCHEMBL20870709 | 0.74 | SMN1; SMN2 (0.40) | CYP2A6SMN1; SMN2CYP1A2LMNATP53 | |
| SCHEMBL28548078 | 0.74 | SMN1; SMN2 (0.40) | SMN1; SMN2LMNATP53 | |
| SCHEMBL692195 | 0.72 | LMNA (0.58) | ALDH1A1SMN1; SMN2HPGDKDM4EMAPT | |
| SCHEMBL29361971 | 0.72 | LMNA (0.58) | ALDH1A1SMN1; SMN2HPGDKDM4EMAPT | |
| Hydrochloric Acid SCHEMBL9688609 | 0.71 | POLB (0.53) | SMN1; SMN2KMT2ACYP1A2MAPTPOLB | |
| SCHEMBL9689857 | 0.70 | MAPT (0.39) | SMN1; SMN2KDM4ECYP1A2MAPTPOLB | |
| SCHEMBL4548300 | 0.69 | HPRT1 (0.39) | HPRT1ALDH1A1HSD17B10TSHRCYP2A6 | |
| SCHEMBL29526949 | 0.64 | PLAU (0.50) | HPRT1ALDH1A1HSD17B10TSHRCYP2A6 | |
| SCHEMBL242954 | 0.64 | PLAU (0.50) | HPRT1ALDH1A1HSD17B10TSHRCYP2A6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0298921-B1 | 1,2-BENZISOXAZOLES AND 1,2-BENZISOTHIAZOLES | CIBA-GEIGY AG (CH) | 1992-12-23 | — | — | EP | disclosed |
| US-4957931-A | ANTICONVULSANTS, TREATMENT OF EPILEPSY | CIBA-GEIGY CORPORATION (US) | 1990-09-18 | — | — | US | disclosed |
| US-4859691-A | Certain 1,2-benzisoxazole derivatives | CIBA-GEIGY CORPORATION (US) | 1989-08-22 | — | — | US | disclosed |
| EP-0298921-A1 | 1,2-Benzisoxazoles and 1,2-benzisothiazoles | CIBA-GEIGY AG (CH) | 1989-01-11 | — | — | EP | disclosed |