Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CACNA1F | O60840 | 1/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
| ▸ | CACNA1D | Q01668 | 1/20 | 0.49 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.49 |
| ▸ | CACNA1S | Q13698 | 1/20 | 0.49 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.49 |
| ▸ | TOP2A | P11388 | 1/20 | 0.48 |
| ▸ | TOP2B | Q02880 | 1/20 | 0.48 |
| ▸ | GSK3B | P49841 | 14/20 | 0.48 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.47 |
| ▸ | STAT3 | P40763 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5704363 | 0.92 | GSK3B (0.51) | CACNA1FPOLBMAPK1CACNA1DKCNH2 | |
| SCHEMBL9133982 | 0.91 | ADRB2 (0.50) | CACNA1FPOLBMAPK1CACNA1DKCNH2 | |
| SCHEMBL15929884 | 0.91 | TOP2A (0.48) | CACNA1FPOLBMAPK1CACNA1DKCNH2 | |
| SCHEMBL1344898 | 0.90 | STAT3 (0.54) | CACNA1FPOLBMAPK1CACNA1DKCNH2 | |
| SCHEMBL6880793 | 0.89 | GSK3B (0.50) | CACNA1FPOLBMAPK1CACNA1DKCNH2 | |
| SCHEMBL8116592 | 0.89 | ADRB2 (0.49) | CACNA1FPOLBMAPK1CACNA1DKCNH2 | |
| SCHEMBL7577114 | 0.87 | ADRB2 (0.47) | CACNA1FPOLBMAPK1CACNA1DKCNH2 | |
| SCHEMBL1344612 | 0.86 | GSK3B (0.49) | CACNA1FPOLBMAPK1CACNA1DKCNH2 | |
| SCHEMBL9585893 | 0.86 | STAT3 (0.54) | CACNA1FPOLBMAPK1CACNA1DKCNH2 | |
| SCHEMBL9688340 | 0.84 | ADRB2 (0.45) | CACNA1FPOLBMAPK1CACNA1DKCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5097032-A | Quinoline- and naphthyridine carboxylic acids, salts | WARNER-LAMBERT COMPANY (US) | 1992-03-17 | — | — | US | disclosed |
| EP-0265230-B1 | SUBSTITUTED-6-FLUORO-4-OXO-1,4-DIHYDROQUINOLINE-3-CARBOXYLIC ACIDS, DERIVATIVES THEREOF, PHARMACEUTICAL COMPOSITIONS COMPRISING THE COMPOUNDS, AND PROCESSES FOR PRODUCING THE COMPOUNDS | WARNER-LAMBERT COMPANY (US) | 1992-01-08 | — | — | EP | disclosed |
| EP-0226961-B1 | 5-AMINO AND 5-HYDROXY-6,8-DIFLUOROQUINOLONES AS ANTIBACTERIAL AGENTS | WARNER-LAMBERT COMPANY (US) | 1991-06-12 | — | — | EP | disclosed |
| US-4977154-A | 7-PIPERAZINE DERIVATIVES | WARNER-LAMBERT COMPANY (US) | 1990-12-11 | — | — | US | disclosed |
| US-4822801-A | 4-oxo-1,4-dihydroquinoline-3-carboxylic acid derivative as antibacterial agents | WARNER-LAMBERT COMPANY (US) | 1989-04-18 | — | — | US | disclosed |
| EP-0265230-A1 | Substituted-6-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acids, derivatives thereof, pharmaceutical compositions comprising the compounds, and processes for producing the compounds | WARNER-LAMBERT COMPANY (US) | 1988-04-27 | — | — | EP | disclosed |
| EP-0226961-A1 | 5-Amino and 5-hydroxy-6,8-difluoroquinolones as antibacterial agents | WARNER-LAMBERT COMPANY (US) | 1987-07-01 | — | — | EP | disclosed |