Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TOP2A | P11388 | 2/20 | 0.55 |
| ▸ | TOP2B | Q02880 | 2/20 | 0.55 |
| ▸ | GSK3B | P49841 | 16/20 | 0.53 |
| ▸ | CACNA1F | O60840 | 1/20 | 0.51 |
| ▸ | POLB | P06746 | 1/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.51 |
| ▸ | CACNA1D | Q01668 | 1/20 | 0.51 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.51 |
| ▸ | CACNA1S | Q13698 | 1/20 | 0.51 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5874340 | 0.87 | TOP2A (0.53) | TOP2ATOP2BGSK3BCACNA1FPOLB | |
| SCHEMBL9088413 | 0.83 | TOP2A (0.48) | TOP2ATOP2BGSK3BCACNA1FPOLB | |
| SCHEMBL9278706 | 0.81 | TOP2A (0.44) | TOP2ATOP2BGSK3BCACNA1FPOLB | |
| SCHEMBL10687663 | 0.79 | RPS6KB1 (0.53) | TOP2ATOP2BGSK3BCACNA1FPOLB | |
| SCHEMBL9162172 | 0.79 | CACNA1F (0.64) | TOP2ATOP2BGSK3BCACNA1FPOLB | |
| SCHEMBL5704411 | 0.79 | GSK3B (0.66) | TOP2ATOP2BGSK3BCACNA1FPOLB | |
| SCHEMBL9689537 | 0.78 | GSK3B (0.68) | TOP2ATOP2BGSK3BCACNA1FPOLB | |
| SCHEMBL10683627 | 0.78 | TOP2A (0.47) | TOP2ATOP2BGSK3BCACNA1FPOLB | |
| SCHEMBL10683888 | 0.77 | KCNH2 (0.50) | TOP2ATOP2BGSK3BCACNA1FPOLB | |
| SCHEMBL1345769 | 0.77 | GSK3B (0.70) | TOP2ATOP2BGSK3BCACNA1FPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0265230-A1 | Substituted-6-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acids, derivatives thereof, pharmaceutical compositions comprising the compounds, and processes for producing the compounds | WARNER-LAMBERT COMPANY (US) | 1988-04-27 | — | — | EP | claimed |
| US-5097032-A | Quinoline- and naphthyridine carboxylic acids, salts | WARNER-LAMBERT COMPANY (US) | 1992-03-17 | — | — | US | disclosed |
| EP-0265230-B1 | SUBSTITUTED-6-FLUORO-4-OXO-1,4-DIHYDROQUINOLINE-3-CARBOXYLIC ACIDS, DERIVATIVES THEREOF, PHARMACEUTICAL COMPOSITIONS COMPRISING THE COMPOUNDS, AND PROCESSES FOR PRODUCING THE COMPOUNDS | WARNER-LAMBERT COMPANY (US) | 1992-01-08 | — | — | EP | disclosed |
| US-4822801-A | 4-oxo-1,4-dihydroquinoline-3-carboxylic acid derivative as antibacterial agents | WARNER-LAMBERT COMPANY (US) | 1989-04-18 | — | — | US | disclosed |
| EP-0265230-A1 | Substituted-6-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acids, derivatives thereof, pharmaceutical compositions comprising the compounds, and processes for producing the compounds | WARNER-LAMBERT COMPANY (US) | 1988-04-27 | — | — | EP | disclosed |