Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TOP2A | P11388 | 5/20 | 0.44 |
| ▸ | TOP2B | Q02880 | 5/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | GSK3B | P49841 | 10/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.39 |
| ▸ | CACNA1F | O60840 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | CACNA1D | Q01668 | 1/20 | 0.39 |
| ▸ | CACNA1S | Q13698 | 1/20 | 0.39 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.39 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.38 |
| ▸ | DPP4 | P27487 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9088413 | 0.87 | TOP2A (0.48) | TOP2ATOP2BMEN1KMT2AGSK3B | |
| SCHEMBL5874340 | 0.85 | TOP2A (0.53) | TOP2ATOP2BMEN1KMT2AGSK3B | |
| SCHEMBL9688663 | 0.81 | TOP2A (0.55) | TOP2ATOP2BMEN1KMT2AGSK3B | |
| SCHEMBL9286042 | 0.81 | MEN1 (0.49) | TOP2ATOP2BMEN1KMT2AGSK3B | |
| SCHEMBL9234629 | 0.81 | MEN1 (0.51) | TOP2ATOP2BMEN1KMT2AGSK3B | |
| SCHEMBL9283024 | 0.79 | KCNH2 (0.48) | TOP2ATOP2BMEN1KMT2AGSK3B | |
| SCHEMBL10379314 | 0.74 | TOP2A (0.44) | TOP2ATOP2BMEN1KMT2AGSK3B | |
| SCHEMBL7576170 | 0.74 | STAT3 (0.44) | TOP2ATOP2BMEN1KMT2AKCNH2 | |
| SCHEMBL14143512 | 0.73 | TOP2A (0.51) | TOP2ATOP2BMEN1KMT2AGSK3B | |
| SCHEMBL500472 | 0.72 | DPP4 (0.57) | TOP2ATOP2BPOLBDPP4KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5585491-A | Antibacterial agents | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1996-12-17 | — | — | US | disclosed |
| EP-0326891-B1 | Antibacterial agents | WARNER LAMBERT CO (US) | 1994-08-03 | — | — | EP | disclosed |
| EP-0544981-A2 | Naphthyridone carboxylic acid derivatives and antibacterial compositions containing them | WARNER-LAMBERT COMPANY (US) | 1993-06-09 | — | — | EP | disclosed |
| EP-0398967-A1 | ANTIBACTERIAL AGENTS | WARNER-LAMBERT COMPANY (US) | 1990-11-28 | — | — | EP | disclosed |
| US-4920120-A | 3-CARBOXY, 4-OXO, 6-FLUORO, 7-NITROGEN-CONTAINING RING 1,4-DIHYDRO-1,8-NAPHTHYRIDINES | WARNER-LAMBERT COMPANY (US) | 1990-04-24 | — | — | US | disclosed |
| EP-0326891-A2 | Antibacterial agents | WARNER-LAMBERT COMPANY (US) | 1989-08-09 | — | — | EP | disclosed |
| WO-1989006649-A2 | ANTIBACTERIAL AGENTS | WARNER-LAMBERT COMPANY (US) | 1989-07-27 | — | — | WO | disclosed |