Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DAO | P14920 | 2/20 | 0.54 |
| ▸ | DDO | Q99489 | 1/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.50 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.50 |
| ▸ | HPGD | P15428 | 2/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.50 |
| ▸ | BRD4 | O60885 | 1/20 | 0.50 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.47 |
| ▸ | KDR | P35968 | 1/20 | 0.47 |
| ▸ | FLT3 | P36888 | 2/20 | 0.47 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.44 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.44 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.44 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.44 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.44 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.44 |
| ▸ | GRIN3A | Q8TCU5 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10969376 | 0.80 | DAO (0.58) | DAOKDM4EMAPTFLT3GRIN2D | |
| SCHEMBL10969990 | 0.80 | DAO (0.58) | DAOKDM4EHSD17B10NPSR1HPGD | |
| SCHEMBL31398830 | 0.77 | BRD4 (0.59) | DAODDOKDM4EHSD17B10NPSR1 | |
| SCHEMBL1833251 | 0.77 | KDM4E (0.55) | DAODDOKDM4EMAPK1HSD17B10 | |
| SCHEMBL250338 | 0.77 | BRD4 (0.59) | DAODDOKDM4EHSD17B10NPSR1 | |
| SCHEMBL17942036 | 0.77 | DAO (0.55) | DAODDOKDM4EMAPK1HSD17B10 | |
| SCHEMBL7058048 | 0.76 | KDM4E (0.52) | KDM4EHSD17B10NPSR1HPGDMAPT | |
| SCHEMBL7809716 | 0.75 | DAO (0.53) | DAODDOKDM4EMAPK1HSD17B10 | |
| SCHEMBL27457766 | 0.75 | DAO (0.51) | DAODDOKDM4EMAPK1HSD17B10 | |
| SCHEMBL9284380 | 0.74 | PDGFRB (0.51) | DAODDOKDM4EMAPK1HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0265230-B1 | SUBSTITUTED-6-FLUORO-4-OXO-1,4-DIHYDROQUINOLINE-3-CARBOXYLIC ACIDS, DERIVATIVES THEREOF, PHARMACEUTICAL COMPOSITIONS COMPRISING THE COMPOUNDS, AND PROCESSES FOR PRODUCING THE COMPOUNDS | WARNER-LAMBERT COMPANY (US) | 1992-01-08 | — | — | EP | claimed |