Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AHR | P35869 | 2/20 | 0.47 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.45 |
| ▸ | PGR | P06401 | 1/20 | 0.45 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.45 |
| ▸ | AR | P10275 | 1/20 | 0.45 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.42 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.41 |
| ▸ | BCHE | P06276 | 3/20 | 0.38 |
| ▸ | BACE1 | P56817 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.34 |
| ▸ | CA1 | P00915 | 1/20 | 0.34 |
| ▸ | CA2 | P00918 | 1/20 | 0.34 |
| ▸ | ITGB2 | P05107 | 1/20 | 0.34 |
| ▸ | ICAM1 | P05362 | 1/20 | 0.34 |
| ▸ | ITGAL | P20701 | 1/20 | 0.34 |
| ▸ | CA4 | P22748 | 1/20 | 0.34 |
| ▸ | CA6 | P23280 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3793079 | 0.84 | AHR (0.50) | AHRNR3C1PGRNR3C2AR | |
| SCHEMBL28743531 | 0.80 | AHR (0.43) | AHRNR3C1PGRNR3C2AR | |
| SCHEMBL14554209 | 0.78 | AHR (0.44) | AHRNR3C1PGRNR3C2AR | |
| SCHEMBL12763890 | 0.78 | AHR (0.44) | AHRNR3C1PGRNR3C2AR | |
| SCHEMBL593971 | 0.76 | KDM4E (0.58) | AHRNR3C1PGRNR3C2AR | |
| SCHEMBL14832511 | 0.72 | KEAP1 (0.49) | AHRNR3C1PGRNR3C2AR | |
| SCHEMBL11726893 | 0.70 | AHR (0.44) | AHRNR3C1PGRNR3C2AR | |
| SCHEMBL27609995 | 0.70 | AHR (0.48) | AHRNR3C1PGRNR3C2AR | |
| SCHEMBL29364263 | 0.69 | AHR (0.56) | AHRNR3C1PGRNR3C2AR | |
| SCHEMBL317549 | 0.69 | AHR (0.56) | AHRNR3C1PGRNR3C2AR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0511879-A1 | Pyrazine derivatives | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1992-11-04 | — | — | EP | disclosed |