Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CASP1 | P29466 | 6/20 | 0.85 |
| ▸ | CASP5 | P51878 | 6/20 | 0.85 |
| ▸ | CASP4 | P49662 | 5/20 | 0.85 |
| ▸ | POLB | P06746 | 1/20 | 0.60 |
| ▸ | SIGMAR1 | Q99720 | 7/20 | 0.58 |
| ▸ | LTA4H | P09960 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10365266 | 0.91 | CASP1 (0.71) | CASP1CASP5CASP4POLBSIGMAR1 | |
| SCHEMBL9702244 | 0.81 | CASP1 (0.64) | CASP1CASP5CASP4SIGMAR1 | |
| SCHEMBL9130732 | 0.80 | CASP1 (0.56) | CASP1CASP5CASP4 | |
| SCHEMBL9129799 | 0.80 | CASP1 (0.62) | CASP1CASP5CASP4SIGMAR1 | |
| SCHEMBL9690236 | 0.80 | CASP1 (0.56) | CASP1CASP5CASP4POLB | |
| SCHEMBL9755198 | 0.79 | CASP1 (0.60) | CASP1CASP5CASP4 | |
| SCHEMBL9688215 | 0.78 | CASP1 (0.55) | CASP1CASP5CASP4 | |
| SCHEMBL9755196 | 0.77 | CASP1 (0.59) | CASP1CASP5CASP4 | |
| SCHEMBL9690413 | 0.77 | CASP1 (0.58) | CASP1CASP5CASP4 | |
| SCHEMBL9689535 | 0.77 | CASP1 (0.58) | CASP1CASP5CASP4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0358676-A1 | PHARMACEUTICALLY ACTIVE AMINES | THE UPJOHN COMPANY (US) | 1990-03-21 | — | — | EP | claimed |
| EP-0293078-A1 | Pharmaceutically active amines | THE UPJOHN COMPANY (US) | 1988-11-30 | — | — | EP | claimed |
| WO-1988008424-A1 | PHARMACEUTICALLY ACTIVE AMINES | THE UPJOHN COMPANY (US) | 1988-11-03 | — | — | WO | claimed |
| EP-0487510-A1 | Pharmaceutically active amines | THE UPJOHN COMPANY (US) | 1992-05-27 | — | — | EP | disclosed |
| EP-0358676-A1 | PHARMACEUTICALLY ACTIVE AMINES | THE UPJOHN COMPANY (US) | 1990-03-21 | — | — | EP | disclosed |
| WO-1988008424-A1 | PHARMACEUTICALLY ACTIVE AMINES | THE UPJOHN COMPANY (US) | 1988-11-03 | — | — | WO | disclosed |