Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 1/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | GSK3B | P49841 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL9860830 | 0.89 | — | — | |
| Hydrochloric Acid SCHEMBL11804062 | 0.89 | — | — | |
| Lithium Ion SCHEMBL6751753 | 0.87 | — | — | |
| Hydrochloric Acid SCHEMBL5028855 | 0.87 | — | — | |
| Lithium Ion SCHEMBL27710560 | 0.87 | — | — | |
| Hydrochloric Acid SCHEMBL737375 | 0.87 | — | — | |
| Lithium Ion SCHEMBL13720140 | 0.87 | — | — | |
| Hydrochloric Acid SCHEMBL9412818 | 0.87 | — | — | |
| Hydrochloric Acid SCHEMBL7158970 | 0.87 | — | — | |
| Lithium Ion SCHEMBL424 | 0.87 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0279125-B1 | TETRAHYDROPYRIDO(1,2-A)INDOLE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | BEECHAM - WUELFING GmbH & Co. KG (DE) | 1992-04-29 | — | — | EP | disclosed |
| US-4968699-A | CENTRAL NERVOUS SYSTEM; ANTIISCHEMIC AND ANTIHYPOXIC AGENTS; ACTIVE AGAINST CEREBRAL OXYGEN DEFICIENCY | BEECHAM-WUELFING GMBH & CO. (DE) | 1990-11-06 | — | — | US | disclosed |
| EP-0167901-B1 | ACTIVE COMPOUNDS | LES LABORATOIRES BEECHAM S.A. (FR) | 1990-04-04 | — | — | EP | disclosed |
| US-4853391-A | Pyrido[1,2-a]indoles and their use as cardiovascular | LABORATOIRES SOBIO SA, 13-15-25 BOULEVARD DE 1'AMIRAL BRUIX 75782 PARIS, CEDEX 16, FRANCE | 1989-08-01 | — | — | US | disclosed |
| US-4837240-A | ANTIISCHEMIC, ANTHIHYPOXIC AGENTS | BEECHAM-WUELFING GMBH & CO. KG (FR) | 1989-06-06 | — | — | US | disclosed |
| EP-0279125-A1 | Tetrahydropyrido(1,2-a)indole derivatives, process for their preparation and pharmaceutical compositions containing them | BEECHAM - WUELFING GmbH & Co. KG (DE) | 1988-08-24 | — | — | EP | disclosed |
| EP-0252643-A1 | Pyrido[1,2-a]indole derivatives, process for their preparation and pharmaceutical compounds containing them | BEECHAM - WUELFING GmbH & Co. KG (DE) | 1988-01-13 | — | — | EP | disclosed |
| EP-0167901-A2 | Active compounds | LES LABORATOIRES BEECHAM S.A. (FR) | 1986-01-15 | — | — | EP | disclosed |