Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 11/20 | 0.43 |
| ▸ | MEN1 | O00255 | 6/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.43 |
| ▸ | POLB | P06746 | 2/20 | 0.43 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | HSPB1 | P04792 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 4/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | GABRP | O00591 | 4/20 | 0.38 |
| ▸ | GABRD | O14764 | 4/20 | 0.38 |
| ▸ | GABRA1 | P14867 | 4/20 | 0.38 |
| ▸ | GABRB1 | P18505 | 4/20 | 0.38 |
| ▸ | GABRG2 | P18507 | 4/20 | 0.38 |
| ▸ | GABRB3 | P28472 | 4/20 | 0.38 |
| ▸ | GABRA5 | P31644 | 4/20 | 0.38 |
| ▸ | GABRA3 | P34903 | 4/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9535825 | 0.91 | KMT2A (0.39) | MAPTMEN1KMT2AKDM4EALDH1A1 | |
| SCHEMBL9688243 | 0.88 | GABRA1 (0.53) | MAPTMEN1KMT2AKDM4EALDH1A1 | |
| SCHEMBL9534414 | 0.82 | GABRA1 (0.44) | MAPTMEN1KMT2AKDM4EALDH1A1 | |
| SCHEMBL9688102 | 0.82 | GABRA1 (0.42) | MAPTMEN1KMT2AKDM4EALDH1A1 | |
| SCHEMBL9689076 | 0.82 | GABRA1 (0.40) | MAPTMEN1KMT2AKDM4EALDH1A1 | |
| SCHEMBL9688766 | 0.82 | GABRA1 (0.46) | MAPTMEN1KMT2AKDM4EALDH1A1 | |
| SCHEMBL11085907 | 0.80 | GABRA1 (0.55) | MAPTMEN1KMT2AKDM4EALDH1A1 | |
| SCHEMBL10767510 | 0.79 | GABRA1 (0.47) | MAPTMEN1KMT2AKDM4EALDH1A1 | |
| SCHEMBL9535165 | 0.78 | GABRA1 (0.40) | MAPTMEN1KMT2AKDM4EPOLB | |
| SCHEMBL9535731 | 0.77 | GABRA1 (0.44) | MAPTMEN1KMT2AKDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0237467-B1 | HETEROARYL-OXY-BETA-CARBOLINE DERIVATIVES, THEIR PREPARATION AND USE AS MEDICAMENTS | SCHERING AKTIENGESELLSCHAFT (DE) | 1992-10-28 | — | — | EP | claimed |
| EP-0237467-B1 | HETEROARYL-OXY-BETA-CARBOLINE DERIVATIVES, THEIR PREPARATION AND USE AS MEDICAMENTS | SCHERING AKTIENGESELLSCHAFT (DE) | 1992-10-28 | — | — | EP | disclosed |