Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GART | P22102 | 18/20 | 0.63 |
| ▸ | ATIC | P31939 | 2/20 | 0.63 |
| ▸ | DHFR | P00374 | 1/20 | 0.55 |
| ▸ | MTHFD1 | P11586 | 1/20 | 0.51 |
| ▸ | MTHFD2 | P13995 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9688511 | 0.96 | GART (0.67) | GARTATICDHFR | |
| SCHEMBL9689132 | 0.94 | GART (0.71) | GARTATICDHFRMTHFD1MTHFD2 | |
| SCHEMBL9688755 | 0.90 | GART (0.76) | GARTATICDHFR | |
| SCHEMBL9689166 | 0.85 | GART (0.65) | GARTATICDHFR | |
| SCHEMBL9687649 | 0.83 | GART (0.66) | GARTATICMTHFD1MTHFD2 | |
| SCHEMBL9688385 | 0.81 | GART (0.70) | GARTATIC | |
| SCHEMBL10520880 | 0.80 | GART (0.56) | GARTATICDHFR | |
| SCHEMBL9689397 | 0.79 | GART (0.73) | GARTATICDHFR | |
| SCHEMBL8342590 | 0.79 | GART (0.76) | GARTATICMTHFD1MTHFD2 | |
| Dideazaacyclotetrahydrofolic Acid SCHEMBL14469101 | 0.77 | GART (1.00) | GARTATIC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0268377-B1 | GLUTAMIC ACID DERIVATIVES, PROCESSES AND INTERMEDIATES FOR THEIR PREPARATION AND PHARMACEUTICAL FORMULATIONS CONTAINING THEM | THE WELLCOME FOUNDATION LIMITED (GB) | 1992-03-18 | — | — | EP | claimed |