Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GART | P22102 | 19/20 | 0.76 |
| ▸ | ATIC | P31939 | 2/20 | 0.76 |
| ▸ | DHFR | P00374 | 1/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9689132 | 0.96 | GART (0.71) | GARTATICDHFR | |
| SCHEMBL9688511 | 0.94 | GART (0.67) | GARTATICDHFR | |
| SCHEMBL9689146 | 0.90 | GART (0.63) | GARTATICDHFR | |
| SCHEMBL9689397 | 0.88 | GART (0.73) | GARTATICDHFR | |
| SCHEMBL5491752 | 0.86 | GART (0.82) | GARTATIC | |
| Dideazaacyclotetrahydrofolic Acid SCHEMBL14469101 | 0.86 | GART (1.00) | GARTATIC | |
| SCHEMBL5673952 | 0.86 | GART (0.82) | GARTATIC | |
| SCHEMBL9794911 | 0.84 | GART (1.00) | GARTATIC | |
| SCHEMBL9688062 | 0.84 | GART (0.79) | GARTATIC | |
| SCHEMBL10419882 | 0.83 | GART (0.80) | GARTATIC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4880812-A | ANTITUMOR AGENTS | BURROUGHS WELLCOME CO. (US) | 1989-11-14 | — | — | US | claimed |
| EP-0268377-B1 | GLUTAMIC ACID DERIVATIVES, PROCESSES AND INTERMEDIATES FOR THEIR PREPARATION AND PHARMACEUTICAL FORMULATIONS CONTAINING THEM | THE WELLCOME FOUNDATION LIMITED (GB) | 1992-03-18 | — | — | EP | disclosed |
| US-4940713-A | ANTITUMOR AGENTS | BURROUGHS WELLCOME CO. (US) | 1990-07-10 | — | — | US | disclosed |
| EP-0268377-A2 | Glutamic acid derivatives, processes and intermediates for their preparation and pharmaceutical formulations containing them | THE WELLCOME FOUNDATION LIMITED (GB) | 1988-05-25 | — | — | EP | disclosed |