Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | PKM | P14618 | 2/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | RECQL | P46063 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.35 |
| ▸ | GFER | P55789 | 1/20 | 0.34 |
| ▸ | EGLN3 | Q9H6Z9 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23043675 | 0.76 | — | — | |
| SCHEMBL5174182 | 0.70 | TLR8 (0.35) | ALDH1A1ALOX15HSD17B10 | |
| SCHEMBL693477 | 0.70 | FNTA (0.47) | HDAC6L3MBTL1POLBMEN1KMT2A | |
| SCHEMBL24350923 | 0.69 | HTR1A (0.35) | ALDH1A1ALOX15MAPTPOLBMEN1 | |
| SCHEMBL24821980 | 0.69 | HTR1A (0.32) | ALDH1A1ALOX15HSD17B10 | |
| Bromide SCHEMBL28813244 | 0.69 | FNTA (0.46) | HDAC6L3MBTL1POLBMEN1KMT2A | |
| SCHEMBL28702022 | 0.68 | HDAC6 (0.41) | HDAC6ALDH1A1NPSR1 | |
| SCHEMBL11588269 | 0.67 | HDAC6 (0.44) | HDAC6ALDH1A1NPSR1PKML3MBTL1 | |
| SCHEMBL1768417 | 0.67 | CYP11B1 (0.41) | HDAC6ALDH1A1NPSR1EGLN3 | |
| SCHEMBL26912264 | 0.67 | HSD17B10 (0.44) | HDAC6HSD17B10NPSR1L3MBTL1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0329357-B1 | DIHYDROPYRIDINE ANTI-ALLERGIC AND ANTI-INFLAMMATORY AGENTS | Pfizer Limited (GB) | 1992-07-15 | — | — | EP | disclosed |
| EP-0329357-A1 | Dihydropyridine anti-allergic and anti-inflammatory agents | Pfizer Limited (GB) | 1989-08-23 | — | — | EP | disclosed |
| US-4859686-A | Dihydropyridine anti-allergic and anti-inflammatory agents | PFIZER INC. (US) | 1989-08-22 | — | — | US | disclosed |