Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.34 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | CBLB | Q13191 | 3/20 | 0.33 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 2/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
| ▸ | POLB | P06746 | 2/20 | 0.31 |
| ▸ | LMNA | P02545 | 2/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | ALB | P02768 | 1/20 | 0.31 |
| ▸ | ESR1 | P03372 | 1/20 | 0.31 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.31 |
| ▸ | RARB | P10826 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31291202 | 0.75 | — | — | |
| SCHEMBL29919959 | 0.75 | — | — | |
| SCHEMBL1491038 | 0.69 | KDM4E (0.50) | ALDH1A1ALOX15HSD17B10L3MBTL1SMN1; SMN2 | |
| SCHEMBL25661195 | 0.69 | CBLB (0.41) | ALDH1A1ALOX15HSD17B10CBLB | |
| SCHEMBL29998114 | 0.68 | CBLB (0.36) | S1PR1CBLB | |
| SCHEMBL30605872 | 0.68 | CBLB (0.36) | S1PR1CBLB | |
| SCHEMBL29998732 | 0.68 | CBLB (0.36) | S1PR1CBLB | |
| SCHEMBL29998458 | 0.68 | CBLB (0.36) | S1PR1CBLB | |
| SCHEMBL29998597 | 0.68 | CBLB (0.36) | S1PR1CBLB | |
| SCHEMBL27263690 | 0.68 | ALDH1A1 (0.31) | ALDH1A1ALOX15HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0329357-B1 | DIHYDROPYRIDINE ANTI-ALLERGIC AND ANTI-INFLAMMATORY AGENTS | Pfizer Limited (GB) | 1992-07-15 | — | — | EP | disclosed |
| EP-0329357-A1 | Dihydropyridine anti-allergic and anti-inflammatory agents | Pfizer Limited (GB) | 1989-08-23 | — | — | EP | disclosed |
| US-4859686-A | Dihydropyridine anti-allergic and anti-inflammatory agents | PFIZER INC. (US) | 1989-08-22 | — | — | US | disclosed |