Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 2/20 | 0.51 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.46 |
| ▸ | MEN1 | O00255 | 3/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | RECQL | P46063 | 2/20 | 0.46 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.42 |
| ▸ | HPGD | P15428 | 3/20 | 0.42 |
| ▸ | CSNK2A1 | P68400 | 3/20 | 0.41 |
| ▸ | CSNK2A2 | P19784 | 2/20 | 0.41 |
| ▸ | CSNK2B | P67870 | 2/20 | 0.41 |
| ▸ | GAA | P10253 | 2/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.40 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.40 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | MDH2 | P40926 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL397484 | 0.81 | CYP1A2 (0.56) | CYP1A2HSD17B10KDM4EMEN1KMT2A | |
| SCHEMBL2309708 | 0.80 | HSD17B10 (0.55) | CYP1A2HSD17B10KDM4EMEN1KMT2A | |
| SCHEMBL2971998 | 0.77 | CYP1A2 (0.55) | CYP1A2HSD17B10KDM4EMEN1KMT2A | |
| SCHEMBL395847 | 0.77 | KDM4E (0.62) | CYP1A2HSD17B10KDM4EMEN1KMT2A | |
| SCHEMBL1353154 | 0.73 | CYP1A2 (0.51) | CYP1A2HSD17B10KDM4EMEN1KMT2A | |
| SCHEMBL2003960 | 0.73 | GAA (0.58) | CYP1A2HSD17B10KDM4EMEN1KMT2A | |
| SCHEMBL7179869 | 0.71 | CYP1A2 (0.43) | CYP1A2HSD17B10HTT | |
| SCHEMBL3995494 | 0.71 | GPR84 (0.51) | CYP1A2HSD17B10KDM4EMEN1KMT2A | |
| SCHEMBL24328929 | 0.70 | SMN1; SMN2 (0.57) | KDM4EMEN1KMT2ARECQLALDH1A1 | |
| SCHEMBL377150 | 0.69 | CFTR (0.67) | CYP1A2HSD17B10KDM4EMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0265230-B1 | SUBSTITUTED-6-FLUORO-4-OXO-1,4-DIHYDROQUINOLINE-3-CARBOXYLIC ACIDS, DERIVATIVES THEREOF, PHARMACEUTICAL COMPOSITIONS COMPRISING THE COMPOUNDS, AND PROCESSES FOR PRODUCING THE COMPOUNDS | WARNER-LAMBERT COMPANY (US) | 1992-01-08 | — | — | EP | disclosed |