Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | PDE4A | P27815 | 1/20 | 0.47 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.40 |
| ▸ | TTPA | P49638 | 2/20 | 0.40 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.39 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.38 |
| ▸ | GSTO1 | P78417 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9690265 | 0.78 | KMT2A (0.48) | MEN1KMT2APDE4APDE3ALMNA | |
| SCHEMBL11705132 | 0.77 | MEN1 (0.61) | MEN1KMT2APDE4APDE3ATTPA | |
| SCHEMBL11706067 | 0.77 | MEN1 (0.61) | MEN1KMT2APDE4APDE3ATTPA | |
| SCHEMBL11706578 | 0.77 | MEN1 (0.61) | MEN1KMT2APDE4APDE3ATTPA | |
| SCHEMBL10346941 | 0.76 | CYP2C19 (0.53) | MEN1KMT2ASMN1; SMN2ALDH1A1KDM4E | |
| SCHEMBL9689458 | 0.76 | MEN1 (0.60) | MEN1KMT2APDE4APDE3ATTPA | |
| SCHEMBL11703482 | 0.76 | MEN1 (0.60) | MEN1KMT2APDE4APDE3ATTPA | |
| SCHEMBL11703489 | 0.76 | MEN1 (0.60) | MEN1KMT2APDE4APDE3ATTPA | |
| SCHEMBL9688320 | 0.76 | MEN1 (0.41) | MEN1KMT2APDE4APDE3AALDH1A1 | |
| SCHEMBL9258885 | 0.75 | MEN1 (0.50) | MEN1KMT2APDE4APDE3ATTPA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0358676-A1 | PHARMACEUTICALLY ACTIVE AMINES | THE UPJOHN COMPANY (US) | 1990-03-21 | — | — | EP | claimed |
| EP-0293078-A1 | Pharmaceutically active amines | THE UPJOHN COMPANY (US) | 1988-11-30 | — | — | EP | claimed |
| WO-1988008424-A1 | PHARMACEUTICALLY ACTIVE AMINES | THE UPJOHN COMPANY (US) | 1988-11-03 | — | — | WO | claimed |
| US-5120843-A | Nervous system disorders | UPJOHN (US) | 1992-06-09 | — | — | US | disclosed |
| EP-0487510-A1 | Pharmaceutically active amines | THE UPJOHN COMPANY (US) | 1992-05-27 | — | — | EP | disclosed |
| EP-0358676-A1 | PHARMACEUTICALLY ACTIVE AMINES | THE UPJOHN COMPANY (US) | 1990-03-21 | — | — | EP | disclosed |
| EP-0293078-A1 | Pharmaceutically active amines | THE UPJOHN COMPANY (US) | 1988-11-30 | — | — | EP | disclosed |
| WO-1988008424-A1 | PHARMACEUTICALLY ACTIVE AMINES | THE UPJOHN COMPANY (US) | 1988-11-03 | — | — | WO | disclosed |