Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | PDE4A | P27815 | 1/20 | 0.48 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.48 |
| ▸ | USP2 | O75604 | 1/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.47 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.47 |
| ▸ | THPO | P40225 | 1/20 | 0.47 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.47 |
| ▸ | LCK | P06239 | 1/20 | 0.47 |
| ▸ | FYN | P06241 | 1/20 | 0.47 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.47 |
| ▸ | DRD2 | P14416 | 1/20 | 0.47 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.47 |
| ▸ | MAPK3 | P27361 | 1/20 | 0.47 |
| ▸ | HTR2C | P28335 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9702265 | 0.87 | CYP3A4 (0.62) | KMT2AMEN1USP2TP53CYP3A4 | |
| SCHEMBL9702365 | 0.80 | CYP3A4 (0.74) | KMT2AMEN1USP2TP53CYP3A4 | |
| SCHEMBL9689341 | 0.78 | MEN1 (0.47) | KMT2AMEN1PDE4APDE3ALMNA | |
| SCHEMBL9688356 | 0.78 | USP2 (0.51) | KMT2AMEN1PDE4APDE3AUSP2 | |
| SCHEMBL9688320 | 0.77 | MEN1 (0.41) | KMT2AMEN1PDE4APDE3ATTPA | |
| SCHEMBL11706578 | 0.76 | MEN1 (0.61) | KMT2AMEN1PDE4APDE3ACYP3A4 | |
| SCHEMBL11705132 | 0.76 | MEN1 (0.61) | KMT2AMEN1PDE4APDE3ACYP3A4 | |
| SCHEMBL11706067 | 0.76 | MEN1 (0.61) | KMT2AMEN1PDE4APDE3ACYP3A4 | |
| SCHEMBL7330589 | 0.76 | MEN1 (0.58) | KMT2AMEN1PDE4APDE3ATTPA | |
| SCHEMBL11703482 | 0.75 | MEN1 (0.60) | KMT2AMEN1PDE4APDE3ACYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0487510-A1 | Pharmaceutically active amines | THE UPJOHN COMPANY (US) | 1992-05-27 | — | — | EP | claimed |
| EP-0293078-A1 | Pharmaceutically active amines | THE UPJOHN COMPANY (US) | 1988-11-30 | — | — | EP | claimed |
| US-5120843-A | Nervous system disorders | UPJOHN (US) | 1992-06-09 | — | — | US | disclosed |