Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 2/20 | 0.74 |
| ▸ | POLB | P06746 | 1/20 | 0.66 |
| ▸ | DRD2 | P14416 | 8/20 | 0.62 |
| ▸ | HTR1A | P08908 | 8/20 | 0.62 |
| ▸ | HTR2A | P28223 | 6/20 | 0.62 |
| ▸ | HTR7 | P34969 | 6/20 | 0.62 |
| ▸ | DRD3 | P35462 | 5/20 | 0.62 |
| ▸ | DRD4 | P21917 | 2/20 | 0.62 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.62 |
| ▸ | DRD1 | P21728 | 2/20 | 0.62 |
| ▸ | DRD5 | P21918 | 2/20 | 0.62 |
| ▸ | HRH1 | P35367 | 2/20 | 0.62 |
| ▸ | HTR6 | P50406 | 3/20 | 0.59 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.58 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9492781 | 0.94 | KCNH2 (0.69) | KCNH2POLBDRD2HTR1AHTR2A | |
| SCHEMBL26108725 | 0.92 | KCNH2 (0.85) | KCNH2POLBDRD2HTR1AHTR2A | |
| SCHEMBL4519313 | 0.92 | KCNH2 (0.85) | KCNH2POLBDRD2HTR1AHTR2A | |
| SCHEMBL26107525 | 0.92 | KCNH2 (0.85) | KCNH2POLBDRD2HTR1AHTR2A | |
| SCHEMBL9689131 | 0.91 | KCNH2 (0.63) | KCNH2POLBDRD2HTR1AHTR2A | |
| Hydrochloric Acid SCHEMBL26108256 | 0.91 | KCNH2 (0.83) | KCNH2POLBDRD2HTR1AHTR2A | |
| SCHEMBL2522222 | 0.88 | POLB (0.64) | KCNH2POLBDRD2HTR1AHTR2A | |
| Hydrochloric Acid SCHEMBL2517441 | 0.86 | POLB (0.62) | KCNH2POLBDRD2HTR1AHTR2A | |
| SCHEMBL4512352 | 0.85 | KCNH2 (1.00) | KCNH2POLBDRD2HTR1AHTR2A | |
| SCHEMBL27715352 | 0.85 | KCNH2 (0.74) | KCNH2POLBDRD2HTR1AHTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0358676-A1 | PHARMACEUTICALLY ACTIVE AMINES | THE UPJOHN COMPANY (US) | 1990-03-21 | — | — | EP | claimed |
| EP-0293078-A1 | Pharmaceutically active amines | THE UPJOHN COMPANY (US) | 1988-11-30 | — | — | EP | claimed |
| WO-1988008424-A1 | PHARMACEUTICALLY ACTIVE AMINES | THE UPJOHN COMPANY (US) | 1988-11-03 | — | — | WO | claimed |
| US-5120843-A | Nervous system disorders | UPJOHN (US) | 1992-06-09 | — | — | US | disclosed |
| EP-0487510-A1 | Pharmaceutically active amines | THE UPJOHN COMPANY (US) | 1992-05-27 | — | — | EP | disclosed |
| EP-0358676-A1 | PHARMACEUTICALLY ACTIVE AMINES | THE UPJOHN COMPANY (US) | 1990-03-21 | — | — | EP | disclosed |
| WO-1988008424-A1 | PHARMACEUTICALLY ACTIVE AMINES | THE UPJOHN COMPANY (US) | 1988-11-03 | — | — | WO | disclosed |