Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 2/20 | 0.74 |
| ▸ | POLB | P06746 | 1/20 | 0.66 |
| ▸ | HTR1A | P08908 | 6/20 | 0.62 |
| ▸ | DRD2 | P14416 | 5/20 | 0.62 |
| ▸ | HTR2A | P28223 | 5/20 | 0.62 |
| ▸ | HTR7 | P34969 | 4/20 | 0.62 |
| ▸ | DRD3 | P35462 | 3/20 | 0.62 |
| ▸ | DRD4 | P21917 | 2/20 | 0.62 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.62 |
| ▸ | DRD1 | P21728 | 2/20 | 0.62 |
| ▸ | DRD5 | P21918 | 2/20 | 0.62 |
| ▸ | HRH1 | P35367 | 2/20 | 0.62 |
| ▸ | HRH3 | Q9Y5N1 | 4/20 | 0.60 |
| ▸ | HTR6 | P50406 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5572065 | 0.94 | KCNH2 (0.69) | KCNH2POLBHTR1ADRD2HTR2A | |
| SCHEMBL26107525 | 0.92 | KCNH2 (0.85) | KCNH2POLBHTR1ADRD2HTR2A | |
| SCHEMBL26108725 | 0.92 | KCNH2 (0.85) | KCNH2POLBHTR1ADRD2HTR2A | |
| SCHEMBL4519313 | 0.92 | KCNH2 (0.85) | KCNH2POLBHTR1ADRD2HTR2A | |
| Hydrochloric Acid SCHEMBL26108256 | 0.91 | KCNH2 (0.83) | KCNH2POLBHTR1ADRD2HTR2A | |
| SCHEMBL10053231 | 0.88 | KCNH2 (0.64) | KCNH2POLBHTR1ADRD2HTR2A | |
| SCHEMBL1332188 | 0.85 | KCNH2 (0.56) | KCNH2POLBHTR1ADRD2HTR2A | |
| SCHEMBL4512352 | 0.85 | KCNH2 (1.00) | KCNH2POLBHTR1ADRD2HTR2A | |
| SCHEMBL9689569 | 0.85 | KCNH2 (0.74) | KCNH2POLBHTR1ADRD2HTR2A | |
| SCHEMBL18301485 | 0.85 | KCNH2 (0.69) | KCNH2POLBHTR1ADRD2HTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101137645-A | Arylpiperazine derivatives for the treatment of neuropsychiatric disorders | UNIV SIENA (IT) | 2008-03-05 | — | — | CN | claimed |
| CN-101137645-A | Arylpiperazine derivatives for the treatment of neuropsychiatric disorders | UNIV SIENA (IT) | 2008-03-05 | — | — | CN | disclosed |