Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.67 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.57 |
| ▸ | SMPD1 | P17405 | 1/20 | 0.57 |
| ▸ | LMNA | P02545 | 1/20 | 0.57 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.57 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.57 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.57 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.57 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.57 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.57 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.57 |
| ▸ | TSHR | P16473 | 1/20 | 0.57 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.57 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.57 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.57 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.57 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.56 |
| ▸ | GLA | P06280 | 1/20 | 0.56 |
| ▸ | BCHE | P06276 | 2/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9689514 | 0.88 | CA1 (0.65) | SMN1; SMN2ALDH1A1SMPD1KDM4EGLA | |
| SCHEMBL4542599 | 0.87 | SMN1; SMN2 (0.64) | SMN1; SMN2ALDH1A1SMPD1LMNANPSR1 | |
| SCHEMBL9073446 | 0.82 | KDM4E (0.64) | SMN1; SMN2ALDH1A1ADRB2KDM4EGLA | |
| SCHEMBL5069115 | 0.82 | BCHE (0.76) | SMN1; SMN2ALDH1A1LMNANPSR1SLC22A1 | |
| SCHEMBL7435099 | 0.78 | ATM (0.76) | SMN1; SMN2ALDH1A1SMPD1ADRB2KDM4E | |
| Hydrochloric Acid SCHEMBL11806441 | 0.77 | ADRB2 (0.71) | ALDH1A1LMNANPSR1SLC22A1ADRB2 | |
| SCHEMBL31364604 | 0.77 | TAAR1 (0.69) | ALDH1A1LMNAADRB2CYP3A4TSHR | |
| Hydrochloric Acid SCHEMBL11808765 | 0.76 | ATM (0.73) | SMN1; SMN2ALDH1A1ADRB2KDM4EGLA | |
| SCHEMBL4103633 | 0.76 | SMPD1 (0.70) | SMN1; SMN2ALDH1A1SMPD1LMNAADRB2 | |
| SCHEMBL5355216 | 0.76 | SMN1; SMN2 (0.62) | SMN1; SMN2ALDH1A1LMNANPSR1SLC22A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0293078-A1 | Pharmaceutically active amines | THE UPJOHN COMPANY (US) | 1988-11-30 | — | — | EP | claimed |
| US-5120843-A | Nervous system disorders | UPJOHN (US) | 1992-06-09 | — | — | US | disclosed |
| EP-0487510-A1 | Pharmaceutically active amines | THE UPJOHN COMPANY (US) | 1992-05-27 | — | — | EP | disclosed |
| EP-0358676-A1 | PHARMACEUTICALLY ACTIVE AMINES | THE UPJOHN COMPANY (US) | 1990-03-21 | — | — | EP | disclosed |
| EP-0293078-A1 | Pharmaceutically active amines | THE UPJOHN COMPANY (US) | 1988-11-30 | — | — | EP | disclosed |
| WO-1988008424-A1 | PHARMACEUTICALLY ACTIVE AMINES | THE UPJOHN COMPANY (US) | 1988-11-03 | — | — | WO | disclosed |