Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TNF | P01375 | 1/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.49 |
| ▸ | PSMB1 | P20618 | 2/20 | 0.48 |
| ▸ | PSMB5 | P28074 | 2/20 | 0.48 |
| ▸ | HTR6 | P50406 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | ACHE | P22303 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | PKM | P14618 | 1/20 | 0.45 |
| ▸ | RECQL | P46063 | 1/20 | 0.45 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 3/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28525147 | 0.81 | TNF (0.59) | TNFKDM4EPSMB1PSMB5ACHE | |
| SCHEMBL29809435 | 0.81 | TNF (0.59) | TNFKDM4EPSMB1PSMB5ACHE | |
| SCHEMBL29809443 | 0.79 | TNF (0.64) | TNFKDM4EPSMB1PSMB5ACHE | |
| SCHEMBL13046538 | 0.78 | TNF (0.56) | TNFKDM4EPSMB1PSMB5MAPT | |
| SCHEMBL1238170 | 0.78 | TNF (0.52) | TNFKDM4EPSMB1PSMB5HTR6 | |
| SCHEMBL179072 | 0.78 | TNF (0.55) | TNFKDM4EPSMB1PSMB5MAPT | |
| SCHEMBL29809320 | 0.78 | TNF (0.55) | TNFKDM4EPSMB1PSMB5MAPT | |
| SCHEMBL4552574 | 0.77 | TNF (0.63) | TNFKDM4EPSMB1PSMB5ACHE | |
| SCHEMBL28525351 | 0.76 | TNF (0.61) | TNFKDM4EACHEHTTTDP1 | |
| SCHEMBL2512199 | 0.76 | CDK4 (0.68) | MAPTALDH1A1KMT2AHTTMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5114952-A | Side effect reduction | PFIZER INC. (US) | 1992-05-19 | — | — | US | disclosed |
| US-4990509-A | Sulfonamide anti-arrhythmic agents | PFIZER INC. (US) | 1991-02-05 | — | — | US | disclosed |
| US-4863948-A | Isoindolinone sulfonamide anti-arrhythmic agents | PFIZER, INC. (US) | 1989-09-05 | — | — | US | disclosed |
| EP-0242173-A1 | Antiarrhythmic agents | Pfizer Limited (GB) | 1987-10-21 | — | — | EP | disclosed |