Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.62 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.62 |
| ▸ | APP | P05067 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.47 |
| ▸ | MEN1 | O00255 | 4/20 | 0.47 |
| ▸ | HPGD | P15428 | 3/20 | 0.47 |
| ▸ | GAA | P10253 | 2/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.47 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.47 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | GLA | P06280 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
| ▸ | AHR | P35869 | 1/20 | 0.47 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.47 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.47 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.47 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3203918 | 0.85 | KDM4E (0.49) | KDM4ETDP1KMT2AALDH1A1MEN1 | |
| SCHEMBL8678798 | 0.81 | KDM4E (0.74) | KDM4ETDP1APPKMT2AALDH1A1 | |
| SCHEMBL1807094 | 0.79 | NR4A2 (0.69) | KDM4EKMT2AALDH1A1MEN1HPGD | |
| SCHEMBL17559719 | 0.78 | MEN1 (0.65) | KDM4ETDP1KMT2AALDH1A1MEN1 | |
| SCHEMBL87871 | 0.78 | KDM4E (0.65) | KDM4ETDP1APPKMT2AALDH1A1 | |
| SCHEMBL27677910 | 0.78 | KDM4E (0.65) | KDM4ETDP1APPKMT2AALDH1A1 | |
| SCHEMBL29415434 | 0.77 | KDM4E (1.00) | KDM4ETDP1APPKMT2AALDH1A1 | |
| SCHEMBL2805779 | 0.77 | KDM4E (1.00) | KDM4ETDP1APPKMT2AALDH1A1 | |
| SCHEMBL570154 | 0.77 | NR4A2 (0.67) | KDM4ETDP1KMT2AALDH1A1MEN1 | |
| SCHEMBL11824092 | 0.77 | KDM4E (0.62) | KDM4ETDP1APPKMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103906732-A | Hydroxamate derivatives for hdac inhibitor, and the pharmaceutical composition comprising thereof | CHONG KUN DANG PHARM CORP | 2014-07-02 | — | — | CN | disclosed |
| CN-1137100-C | Tricyclic compounds capable of inhibiting tyrosine kinases of the epidermal growth factor receptor family | ��ʲ | 2004-02-04 | — | — | CN | disclosed |
| CN-1139430-A | Tricyclic compounds capable of inhibiting tyrosine kinases of the epidermal growth factor receptor family | WARNER LAMBERT CO (US) | 1997-01-01 | — | — | CN | disclosed |
| EP-0249301-B1 | Pyrido[2,3-b]indoles | BEECHAM GROUP PLC (GB) | 1992-05-27 | — | — | EP | disclosed |
| US-4952584-A | TREATMENT OF PROPHYLAXIS OF ANXIETY OR DEPRESSION | BEECHAM GROUP P.L.C. (GB) | 1990-08-28 | — | — | US | disclosed |
| EP-0249301-A1 | Pyrido[2,3-b]indoles | BEECHAM GROUP PLC (GB) | 1987-12-16 | — | — | EP | disclosed |