SCHEMBL9690654

SCHEMBL9690654

FC(F)(F)c1cccc(/N=N/C2=NCCS2)c1

nearest known ligand 0.55

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPT P10636 7/20 0.55
MEN1 O00255 5/20 0.55
KMT2A Q03164 5/20 0.55
SMN1; SMN2 Q16637 5/20 0.55
HTT P42858 4/20 0.55
LMNA P02545 3/20 0.55
KDM4E B2RXH2 2/20 0.55
RAB9A P51151 2/20 0.55
TDP1 Q9NUW8 2/20 0.55
HTR3E A5X5Y0 1/20 0.42
HTR3B O95264 1/20 0.42
HTR3A P46098 1/20 0.42
HTR3D Q70Z44 1/20 0.42
HTR3C Q8WXA8 1/20 0.42
ESR1 P03372 1/20 0.38
ESR2 Q92731 1/20 0.38
GAA P10253 2/20 0.37
NPSR1 Q6W5P4 4/20 0.37
ALDH1A1 P00352 2/20 0.37
HSP90AA1 P07900 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9690661 1.00 MAPT (0.55) MAPTMEN1KMT2ASMN1; SMN2HTT
SCHEMBL9688567 0.89 KMT2A (0.45) MAPTMEN1KMT2ASMN1; SMN2HTT
SCHEMBL9688581 0.89 KMT2A (0.45) MAPTMEN1KMT2ASMN1; SMN2HTT
SCHEMBL9690589 0.86 MEN1 (0.42) MAPTMEN1KMT2ASMN1; SMN2HTT
SCHEMBL9690586 0.86 MEN1 (0.42) MAPTMEN1KMT2ASMN1; SMN2HTT
SCHEMBL9661588 0.82 NPC1 (0.44) MAPTMEN1KMT2ASMN1; SMN2HTT
SCHEMBL9661581 0.82 NPC1 (0.44) MAPTMEN1KMT2ASMN1; SMN2HTT
SCHEMBL9690672 0.81 KMT2A (0.50) MAPTMEN1KMT2ASMN1; SMN2HTT
SCHEMBL9690057 0.80 KDM4E (0.38) MAPTMEN1KMT2ASMN1; SMN2HTT
SCHEMBL9690064 0.80 KDM4E (0.38) MAPTMEN1KMT2ASMN1; SMN2HTT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0520275-A2 2-(3-Substituted phenylhydrazino)-2-thiazoline and 2-(3-substituted phenylazo)-2-thiazoline, their preparation and their use against ectoparasites BAYER AG (DE) 1992-12-30 EP disclosed