Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Oxalic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 known ✓ | P31645 | 1/20 | 0.42 |
| ▸ | OPRM1 known ✓ | P35372 | 1/20 | 0.42 |
| ▸ | SSTR5 | P35346 | 5/20 | 0.46 |
| ▸ | KCNH2 | Q12809 | 7/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | GAA | P10253 | 2/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | NR4A2 | P43354 | 2/20 | 0.43 |
| ▸ | HTT | P42858 | 2/20 | 0.42 |
| ▸ | HRH1 | P35367 | 2/20 | 0.42 |
| ▸ | HRH4 | Q9H3N8 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | MLNR | O43193 | 1/20 | 0.42 |
| ▸ | CACNA1F | O60840 | 1/20 | 0.42 |
| ▸ | EED | O75530 | 1/20 | 0.42 |
| ▸ | USP2 | O75604 | 1/20 | 0.42 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Oxalic Acid SCHEMBL9690852 | 1.00 | SSTR5 (0.46) | SSTR5KCNH2TSHRLMNAGAA | |
| SCHEMBL14198334 | 0.92 | TSHR (0.52) | SSTR5KCNH2TSHRLMNAGAA | |
| Oxalic Acid SCHEMBL9630277 | 0.90 | SSTR5 (0.49) | SSTR5KCNH2TSHRLMNAGAA | |
| Oxalic Acid SCHEMBL9630287 | 0.90 | SSTR5 (0.49) | SSTR5KCNH2TSHRLMNAGAA | |
| SCHEMBL9630514 | 0.87 | SSTR5 (0.48) | SSTR5KCNH2TSHRLMNAGAA | |
| SCHEMBL9387373 | 0.87 | SSTR5 (0.46) | SSTR5KCNH2LMNAGAAALDH1A1 | |
| Oxalic Acid SCHEMBL9630637 | 0.87 | MEN1 (0.42) | LMNAGAAALDH1A1MEN1TP53 | |
| Oxalic Acid SCHEMBL9630643 | 0.87 | MEN1 (0.42) | LMNAGAAALDH1A1MEN1TP53 | |
| SCHEMBL9629456 | 0.85 | KDM4E (0.50) | SSTR5TSHRLMNAGAAALDH1A1 | |
| Oxalic Acid SCHEMBL9630530 | 0.85 | SSTR5 (0.44) | SSTR5KCNH2TSHRLMNAGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0297661-B1 | [(Bicyclic heterocyclyl)methyl and -hetero] substituted hexahydro-1H-azepines and pyrrolidines | JANSSEN PHARMACEUTICA N.V. (BE) | 1992-09-16 | — | — | EP | disclosed |
| US-5071846-A | Anti-hystaminic [(bicyclic heterocyclyl) methyl and --hetero] substituted hexahydro-1H-azepines and pyrrolidines | JANSSEN PHARMACEUTICA N.V. (BE) | 1991-12-10 | — | — | US | disclosed |
| US-4988689-A | Antiallergens, antihistamines | JANSSEN PHARMACEUTICA N.V. (BE) | 1991-01-29 | — | — | US | disclosed |