Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Oxalic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 known ✓ | P35372 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | TP53 | P04637 | 4/20 | 0.39 |
| ▸ | ENPP2 | Q13822 | 2/20 | 0.38 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.37 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.37 |
| ▸ | SSTR4 | P31391 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Oxalic Acid SCHEMBL9630643 | 1.00 | MEN1 (0.42) | MEN1KMT2AALDH1A1HPGDMAPT | |
| SCHEMBL9687066 | 0.92 | RET (0.39) | MEN1KMT2AALDH1A1MAPTTP53 | |
| Oxalic Acid SCHEMBL9807286 | 0.89 | ALDH1A1 (0.41) | MEN1KMT2AALDH1A1HPGDMAPT | |
| Oxalic Acid SCHEMBL9807288 | 0.89 | ALDH1A1 (0.41) | MEN1KMT2AALDH1A1HPGDMAPT | |
| Oxalic Acid SCHEMBL9687737 | 0.88 | MEN1 (0.42) | MEN1KMT2AALDH1A1HPGDMAPT | |
| Oxalic Acid SCHEMBL9687735 | 0.88 | MEN1 (0.42) | MEN1KMT2AALDH1A1HPGDMAPT | |
| Oxalic Acid SCHEMBL9629530 | 0.87 | MEN1 (0.40) | MEN1KMT2AALDH1A1HPGDMAPT | |
| Oxalic Acid SCHEMBL9629525 | 0.87 | MEN1 (0.40) | MEN1KMT2AALDH1A1HPGDMAPT | |
| Oxalic Acid SCHEMBL9629562 | 0.87 | TSHR (0.42) | MEN1KMT2AALDH1A1HPGDMAPT | |
| Oxalic Acid SCHEMBL9629553 | 0.87 | TSHR (0.42) | MEN1KMT2AALDH1A1HPGDMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5151424-A | Antiallergens or antihistamines | JANSSEN PHARMACEUTICA N.V. (BE) | 1992-09-29 | — | — | US | disclosed |
| EP-0297661-B1 | [(Bicyclic heterocyclyl)methyl and -hetero] substituted hexahydro-1H-azepines and pyrrolidines | JANSSEN PHARMACEUTICA N.V. (BE) | 1992-09-16 | — | — | EP | disclosed |
| US-5071846-A | Anti-hystaminic [(bicyclic heterocyclyl) methyl and --hetero] substituted hexahydro-1H-azepines and pyrrolidines | JANSSEN PHARMACEUTICA N.V. (BE) | 1991-12-10 | — | — | US | disclosed |
| US-4988689-A | Antiallergens, antihistamines | JANSSEN PHARMACEUTICA N.V. (BE) | 1991-01-29 | — | — | US | disclosed |