Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRP | O00591 | 8/20 | 0.77 |
| ▸ | GABRD | O14764 | 8/20 | 0.77 |
| ▸ | GABRA1 | P14867 | 8/20 | 0.77 |
| ▸ | GABRB1 | P18505 | 8/20 | 0.77 |
| ▸ | GABRG2 | P18507 | 8/20 | 0.77 |
| ▸ | GABRB3 | P28472 | 8/20 | 0.77 |
| ▸ | GABRA5 | P31644 | 8/20 | 0.77 |
| ▸ | GABRA3 | P34903 | 8/20 | 0.77 |
| ▸ | GABRA2 | P47869 | 8/20 | 0.77 |
| ▸ | GABRB2 | P47870 | 8/20 | 0.77 |
| ▸ | GABRA4 | P48169 | 8/20 | 0.77 |
| ▸ | GABRE | P78334 | 8/20 | 0.77 |
| ▸ | GABRA6 | Q16445 | 8/20 | 0.77 |
| ▸ | GABRG1 | Q8N1C3 | 8/20 | 0.77 |
| ▸ | GABRG3 | Q99928 | 8/20 | 0.77 |
| ▸ | GABRQ | Q9UN88 | 8/20 | 0.77 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.49 |
| ▸ | HPGD | P15428 | 5/20 | 0.49 |
| ▸ | POLB | P06746 | 2/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9690539 | 0.88 | GABRP (0.61) | GABRPGABRDGABRA1GABRB1GABRG2 | |
| SCHEMBL9690380 | 0.88 | GABRP (0.61) | GABRPGABRDGABRA1GABRB1GABRG2 | |
| SCHEMBL9690959 | 0.86 | GABRP (0.59) | GABRPGABRDGABRA1GABRB1GABRG2 | |
| SCHEMBL9690931 | 0.86 | GABRP (0.59) | GABRPGABRDGABRA1GABRB1GABRG2 | |
| SCHEMBL10462443 | 0.85 | GABRP (0.58) | GABRPGABRDGABRA1GABRB1GABRG2 | |
| SCHEMBL9688866 | 0.84 | GABRP (0.76) | GABRPGABRDGABRA1GABRB1GABRG2 | |
| SCHEMBL9690457 | 0.82 | GABRP (0.59) | GABRPGABRDGABRA1GABRB1GABRG2 | |
| SCHEMBL10463260 | 0.73 | GABRP (0.61) | GABRPGABRDGABRA1GABRB1GABRG2 | |
| SCHEMBL14896458 | 0.73 | KDM4E (0.66) | ALDH1A1KDM4EHPGDPOLBHSD17B10 | |
| SCHEMBL9690819 | 0.71 | GABRP (0.53) | GABRPGABRDGABRA1GABRB1GABRG2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0249301-A1 | Pyrido[2,3-b]indoles | BEECHAM GROUP PLC (GB) | 1987-12-16 | — | — | EP | claimed |
| EP-0249301-B1 | Pyrido[2,3-b]indoles | BEECHAM GROUP PLC (GB) | 1992-05-27 | — | — | EP | disclosed |
| US-4952584-A | TREATMENT OF PROPHYLAXIS OF ANXIETY OR DEPRESSION | BEECHAM GROUP P.L.C. (GB) | 1990-08-28 | — | — | US | disclosed |
| EP-0249301-A1 | Pyrido[2,3-b]indoles | BEECHAM GROUP PLC (GB) | 1987-12-16 | — | — | EP | disclosed |