Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 7/20 | 0.68 |
| ▸ | NPC1 | O15118 | 5/20 | 0.68 |
| ▸ | RAB9A | P51151 | 5/20 | 0.68 |
| ▸ | LMNA | P02545 | 1/20 | 0.64 |
| ▸ | PKM | P14618 | 2/20 | 0.57 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.54 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.54 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.54 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.54 |
| ▸ | CASP3 | P42574 | 1/20 | 0.54 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.54 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.54 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.54 |
| ▸ | DPP4 | P27487 | 1/20 | 0.54 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.54 |
| ▸ | MEN1 | O00255 | 4/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | POLB | P06746 | 2/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6657973 | 0.91 | LMNA (0.68) | MAPTNPC1RAB9ALMNAPKM | |
| SCHEMBL14099477 | 0.84 | MAPT (0.68) | MAPTNPC1RAB9ALMNAPKM | |
| SCHEMBL7369725 | 0.84 | MAPT (0.68) | MAPTNPC1RAB9ALMNAPKM | |
| SCHEMBL8288918 | 0.82 | LMNA (0.64) | MAPTNPC1RAB9ALMNAPKM | |
| SCHEMBL29306419 | 0.81 | LMNA (0.64) | MAPTNPC1RAB9ALMNAPKM | |
| SCHEMBL5848968 | 0.81 | LMNA (0.75) | MAPTNPC1RAB9ALMNAPKM | |
| SCHEMBL13964086 | 0.81 | NPC1 (0.62) | MAPTNPC1RAB9ALMNAPKM | |
| SCHEMBL4034758 | 0.81 | NPC1 (0.62) | MAPTNPC1RAB9ALMNAPKM | |
| SCHEMBL9977934 | 0.81 | MAPT (0.63) | MAPTNPC1RAB9ALMNAPKM | |
| SCHEMBL9392247 | 0.81 | NPC1 (1.00) | MAPTNPC1RAB9ALMNAPKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0294074-B1 | DIHYDROPYRIDINE ANTI-ALLERGIC AND ANTI-INFLAMMATORY AGENTS | Pfizer Limited (GB) | 1992-04-08 | — | — | EP | disclosed |
| US-4851412-A | ASTHMA, ARTHRITIS | PFIZER INC. (US) | 1989-07-25 | — | — | US | disclosed |
| EP-0294074-A1 | Dihydropyridine anti-allergic and anti-inflammatory agents | Pfizer Limited (GB) | 1988-12-07 | — | — | EP | disclosed |