Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EED | O75530 | 2/20 | 0.51 |
| ▸ | SSTR5 | P35346 | 5/20 | 0.50 |
| ▸ | KCNH2 | Q12809 | 10/20 | 0.49 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | MLNR | O43193 | 1/20 | 0.46 |
| ▸ | CACNA1F | O60840 | 1/20 | 0.46 |
| ▸ | USP2 | O75604 | 1/20 | 0.46 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.46 |
| ▸ | EGFR | P00533 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | HLA-A | P04439 | 1/20 | 0.46 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | LCK | P06239 | 1/20 | 0.46 |
| ▸ | FYN | P06241 | 1/20 | 0.46 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9740847 | 0.94 | SSTR5 (0.54) | EEDSSTR5KCNH2NR4A2SMN1; SMN2 | |
| Fumaric Acid SCHEMBL9629590 | 0.92 | SSTR5 (0.46) | EEDSSTR5KCNH2NR4A2SMN1; SMN2 | |
| SCHEMBL9689139 | 0.87 | EED (0.47) | EEDSSTR5KCNH2NR4A2SMN1; SMN2 | |
| SCHEMBL9629312 | 0.86 | SLC6A9 (0.47) | EEDSSTR5KCNH2MAPTTP53 | |
| SCHEMBL9630426 | 0.86 | EED (0.47) | EEDSSTR5KCNH2NR4A2SMN1; SMN2 | |
| SCHEMBL9741215 | 0.82 | KCNH2 (0.55) | EEDSSTR5KCNH2NR4A2SMN1; SMN2 | |
| SCHEMBL9629523 | 0.82 | EED (0.74) | EEDSSTR5KCNH2NR4A2SMN1; SMN2 | |
| SCHEMBL9630130 | 0.82 | HRH1 (0.53) | EEDSSTR5KCNH2NR4A2SMN1; SMN2 | |
| Oxalic Acid SCHEMBL9630409 | 0.81 | SSTR5 (0.45) | EEDSSTR5KCNH2NR4A2SMN1; SMN2 | |
| Oxalic Acid SCHEMBL9630418 | 0.81 | SSTR5 (0.45) | EEDSSTR5KCNH2NR4A2SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0297661-B1 | [(Bicyclic heterocyclyl)methyl and -hetero] substituted hexahydro-1H-azepines and pyrrolidines | JANSSEN PHARMACEUTICA N.V. (BE) | 1992-09-16 | — | — | EP | disclosed |