Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 2/20 | 0.50 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | TNF | P01375 | 2/20 | 0.41 |
| ▸ | P2RX7 | Q99572 | 3/20 | 0.41 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.41 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 2/20 | 0.40 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.40 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | NCF1 | P14598 | 1/20 | 0.39 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.39 |
| ▸ | YTHDC1 | Q96MU7 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10581641 | 0.83 | BRD4 (0.51) | BRD4HPGDPOLBTNFP2RX7 | |
| SCHEMBL9786782 | 0.80 | BRD4 (0.63) | BRD4HPGDLMNATSHRCYP11B1 | |
| SCHEMBL19906468 | 0.80 | P2RX7 (0.57) | BRD4HPGDP2RX7 | |
| SCHEMBL9786781 | 0.79 | CYP19A1 (0.61) | BRD4HPGDTNFP2RX7NOTUM | |
| Hydrochloric Acid SCHEMBL27858742 | 0.79 | BRD4 (0.48) | BRD4HPGDTNFP2RX7NOTUM | |
| SCHEMBL28714989 | 0.78 | BRD4 (0.58) | BRD4HPGDLMNACYP11B1CYP11B2 | |
| SCHEMBL19111414 | 0.77 | BRD4 (0.47) | BRD4HPGDLMNATNFP2RX7 | |
| SCHEMBL28710551 | 0.76 | NOTUM (0.50) | BRD4HPGDLMNAPOLBP2RX7 | |
| SCHEMBL9638057 | 0.76 | BRD4 (0.46) | BRD4HPGDPOLBP2RX7TSHR | |
| SCHEMBL2053376 | 0.76 | BRD4 (0.56) | BRD4HPGDLMNANOTUMNPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5114961-A | 2,5-diaryl tetrahydrofurans and analogs thereof as PAF antagonists | MERCK & CO., INC. (US) | 1992-05-19 | — | — | US | disclosed |
| US-4996203-A | Platelet-activating factor antagonists | MERCK & CO., INC. (US) | 1991-02-26 | — | — | US | disclosed |
| EP-0402150-A1 | New 2,5-diaryl tetrahydrofurans and analogs therof as PAF antagonists | MERCK & CO. INC. (US) | 1990-12-12 | — | — | EP | disclosed |