Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 8/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.61 |
| ▸ | TP53 | P04637 | 1/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | LGMN | Q99538 | 2/20 | 0.47 |
| ▸ | CTSB | P07858 | 1/20 | 0.46 |
| ▸ | VCAM1 | P19320 | 1/20 | 0.44 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9693529 | 1.00 | MAPT (0.61) | MAPTALDH1A1TP53HTTLGMN | |
| SCHEMBL9693729 | 0.90 | ALDH1A1 (0.51) | MAPTALDH1A1HTTMEN1KMT2A | |
| SCHEMBL9693725 | 0.90 | ALDH1A1 (0.51) | MAPTALDH1A1HTTMEN1KMT2A | |
| SCHEMBL9691817 | 0.86 | MAPT (0.53) | MAPTALDH1A1HTTMEN1KMT2A | |
| SCHEMBL9691823 | 0.86 | MAPT (0.53) | MAPTALDH1A1HTTMEN1KMT2A | |
| SCHEMBL9692032 | 0.83 | MAPT (0.72) | MAPTALDH1A1TP53HTTLGMN | |
| SCHEMBL9694051 | 0.81 | PDE3B (0.49) | MAPTALDH1A1TP53MEN1KMT2A | |
| SCHEMBL9694044 | 0.81 | PDE3B (0.49) | MAPTALDH1A1TP53MEN1KMT2A | |
| SCHEMBL9693493 | 0.80 | MAPT (0.51) | MAPTALDH1A1MEN1KMT2AKDM4E | |
| SCHEMBL9693489 | 0.80 | MAPT (0.51) | MAPTALDH1A1MEN1KMT2AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0252503-B1 | AMINOIMIDAZOQUINOLINE DERIVATIVES | Bristol-Myers Squibb Company (US) | 1992-11-19 | — | — | EP | disclosed |
| EP-0252503-A1 | Aminoimidazoquinoline derivatives | Bristol-Myers Squibb Company (US) | 1988-01-13 | — | — | EP | disclosed |
| US-4701459-A | 7-amino-1,3-dihydro-2H-imidazo[4,5-b]quinolin 2-ones and method for inhibiting phosphodiesterase and blood platelet aggregation | BRISTOL-MYERS COMPANY (US) | 1987-10-20 | — | — | US | disclosed |