Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 7/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.40 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 3/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.37 |
| ▸ | CDK2 | P24941 | 1/20 | 0.37 |
| ▸ | CTSB | P07858 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | SERPINE1 | P05121 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9693775 | 1.00 | MAPT (0.42) | MAPTALDH1A1MAPK1PDE3BPDE3A | |
| SCHEMBL9694044 | 0.91 | PDE3B (0.49) | MAPTALDH1A1MAPK1PDE3BPDE3A | |
| SCHEMBL9694051 | 0.91 | PDE3B (0.49) | MAPTALDH1A1MAPK1PDE3BPDE3A | |
| SCHEMBL10744861 | 0.85 | MAPT (0.49) | MAPTALDH1A1MAPK1PDE3BPDE3A | |
| SCHEMBL9693729 | 0.83 | ALDH1A1 (0.51) | MAPTALDH1A1MAPK1KDM4ECYP1A2 | |
| SCHEMBL9693725 | 0.83 | ALDH1A1 (0.51) | MAPTALDH1A1MAPK1KDM4ECYP1A2 | |
| SCHEMBL9691943 | 0.79 | HPGD (0.51) | MAPTALDH1A1MAPK1GAALMNA | |
| SCHEMBL9691948 | 0.79 | HPGD (0.51) | MAPTALDH1A1MAPK1GAALMNA | |
| SCHEMBL9693493 | 0.78 | MAPT (0.51) | MAPTALDH1A1MAPK1GAALMNA | |
| SCHEMBL9693489 | 0.78 | MAPT (0.51) | MAPTALDH1A1MAPK1GAALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0252503-B1 | AMINOIMIDAZOQUINOLINE DERIVATIVES | Bristol-Myers Squibb Company (US) | 1992-11-19 | — | — | EP | disclosed |
| US-4701459-A | 7-amino-1,3-dihydro-2H-imidazo[4,5-b]quinolin 2-ones and method for inhibiting phosphodiesterase and blood platelet aggregation | BRISTOL-MYERS COMPANY (US) | 1987-10-20 | — | — | US | disclosed |