Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.67 |
| ▸ | POLB | P06746 | 4/20 | 0.67 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.67 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.67 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.67 |
| ▸ | MAPT | P10636 | 10/20 | 0.58 |
| ▸ | ALDH1A3 | P47895 | 1/20 | 0.58 |
| ▸ | LMNA | P02545 | 5/20 | 0.57 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.57 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.57 |
| ▸ | CTSB | P07858 | 1/20 | 0.54 |
| ▸ | AR | P10275 | 1/20 | 0.54 |
| ▸ | GAA | P10253 | 2/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.51 |
| ▸ | TNNI3 | P19429 | 2/20 | 0.49 |
| ▸ | TNNT2 | P45379 | 2/20 | 0.49 |
| ▸ | TNNC1 | P63316 | 2/20 | 0.49 |
| ▸ | MEN1 | O00255 | 2/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | USP2 | O75604 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9691740 | 0.98 | ALDH1A1 (0.69) | ALDH1A1POLBCYP1A2CYP2C19CYP2C9 | |
| SCHEMBL9694011 | 0.85 | MAPT (0.52) | ALDH1A1POLBCYP1A2CYP2C19CYP2C9 | |
| SCHEMBL10602573 | 0.77 | ALDH1A1 (0.63) | ALDH1A1POLBCYP1A2CYP2C19CYP2C9 | |
| SCHEMBL10600576 | 0.77 | ALDH1A1 (0.63) | ALDH1A1POLBCYP1A2CYP2C19CYP2C9 | |
| SCHEMBL20696980 | 0.76 | ALDH1A1 (0.63) | ALDH1A1POLBCYP1A2CYP2C19CYP2C9 | |
| SCHEMBL272834 | 0.75 | TDP1 (0.62) | ALDH1A1MAPK1MEN1KMT2A | |
| SCHEMBL1419188 | 0.74 | ALDH1A1 (1.00) | ALDH1A1POLBCYP1A2CYP2C19CYP2C9 | |
| SCHEMBL28382330 | 0.74 | ALDH1A1 (0.83) | ALDH1A1POLBCYP1A2CYP2C19MAPT | |
| SCHEMBL5093165 | 0.73 | POLB (1.00) | ALDH1A1POLBCYP1A2CYP2C19CYP2C9 | |
| SCHEMBL23486528 | 0.73 | ALDH1A1 (1.00) | ALDH1A1POLBCYP1A2CYP2C19CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0252503-B1 | AMINOIMIDAZOQUINOLINE DERIVATIVES | Bristol-Myers Squibb Company (US) | 1992-11-19 | — | — | EP | disclosed |
| EP-0252503-A1 | Aminoimidazoquinoline derivatives | Bristol-Myers Squibb Company (US) | 1988-01-13 | — | — | EP | disclosed |
| US-4701459-A | 7-amino-1,3-dihydro-2H-imidazo[4,5-b]quinolin 2-ones and method for inhibiting phosphodiesterase and blood platelet aggregation | BRISTOL-MYERS COMPANY (US) | 1987-10-20 | — | — | US | disclosed |