Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | PRKCA | P17252 | 2/20 | 0.32 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.32 |
| ▸ | PRKCG | P05129 | 1/20 | 0.32 |
| ▸ | PRKCB | P05771 | 1/20 | 0.32 |
| ▸ | PRKCH | P24723 | 1/20 | 0.32 |
| ▸ | PRKCE | Q02156 | 1/20 | 0.32 |
| ▸ | PRKCQ | Q04759 | 1/20 | 0.32 |
| ▸ | PRKCD | Q05655 | 1/20 | 0.32 |
| ▸ | PRKD1 | Q15139 | 1/20 | 0.32 |
| ▸ | CHRM2 | P08172 | 4/20 | 0.32 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.32 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.32 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1009073 | 0.95 | POLB (0.38) | POLBGAACYP3A4LMNAPRKCA | |
| SCHEMBL20799299 | 0.87 | POLB (0.35) | POLBCYP3A4LMNACHRM2CHRM1 | |
| SCHEMBL18946815 | 0.87 | POLB (0.35) | POLBCYP3A4LMNACHRM2CHRM1 | |
| SCHEMBL7155657 | 0.83 | POLB (0.36) | POLBGAACYP3A4LMNACHRM2 | |
| SCHEMBL14566775 | 0.77 | CHRM2 (0.34) | POLBCYP3A4CHRM2CHRM1CHRM4 | |
| SCHEMBL11413331 | 0.76 | CA1 (0.34) | POLBGAACYP3A4CYP2D6 | |
| SCHEMBL8749108 | 0.72 | POLB (0.33) | POLBGAAPRKCAPRKD3PRKCG | |
| SCHEMBL24145355 | 0.71 | POLB (0.38) | POLBGAACYP3A4CHRM2CHRM1 | |
| SCHEMBL220405 | 0.71 | POLB (0.38) | POLBGAACYP3A4CHRM2CHRM1 | |
| SCHEMBL17928956 | 0.71 | POLB (0.38) | POLBGAACYP3A4CHRM2CHRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0463470-A2 | Process for the preparation of a fluorotetrahydrofuranone derivative | F. HOFFMANN-LA ROCHE AG (CH) | 1992-01-02 | — | — | EP | disclosed |