Known targets — ChEMBL curated mechanism
ACHECHKACHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGHRH2OPRM1
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE known ✓ | P22303 | 2/20 | 0.31 |
| ▸ | MAPT | P10636 | 8/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.48 |
| ▸ | HPGD | P15428 | 5/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | ADRB2 | P07550 | 2/20 | 0.35 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.35 |
| ▸ | INSR | P06213 | 1/20 | 0.33 |
| ▸ | SNCA | P37840 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2271462 | 0.98 | KDM4E (0.46) | MAPTKDM4EALDH1A1HPGDMEN1 | |
| SCHEMBL29496561 | 0.98 | KDM4E (0.46) | MAPTKDM4EALDH1A1HPGDMEN1 | |
| Iodide SCHEMBL2234372 | 0.95 | KDM4E (0.44) | MAPTKDM4EALDH1A1HPGDMEN1 | |
| Iodide SCHEMBL6093239 | 0.95 | KDM4E (0.44) | MAPTKDM4EALDH1A1HPGDMEN1 | |
| Hydrochloric Acid SCHEMBL7776252 | 0.95 | KDM4E (0.44) | MAPTKDM4EALDH1A1HPGDMEN1 | |
| Iodide SCHEMBL29496722 | 0.95 | KDM4E (0.44) | MAPTKDM4EALDH1A1HPGDMEN1 | |
| Perchlorate SCHEMBL142055 | 0.90 | MAPT (0.41) | MAPTKDM4EALDH1A1HPGDMEN1 | |
| SCHEMBL22320975 | 0.90 | KDM4E (0.41) | MAPTKDM4EALDH1A1HPGDMEN1 | |
| SCHEMBL6754886 | 0.90 | KDM4E (0.41) | MAPTKDM4EALDH1A1HPGDMEN1 | |
| Perchlorate SCHEMBL29551365 | 0.90 | MAPT (0.41) | MAPTKDM4EALDH1A1HPGDMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0474387-A1 | Synthesis of alpha-hydroxy ketones | BP Chemicals Limited (GB) | 1992-03-11 | — | — | EP | disclosed |
| US-5087761-A | Condensing aldehydes in liquid phase with active catalyst formed by removing anion from thiazolium salt | BP CHEMICALS LIMITED (GB) | 1992-02-11 | — | — | US | disclosed |
| EP-0410613-A1 | Synthesis of alpha-hydroxy ketones | BP Chemicals Limited (GB) | 1991-01-30 | — | — | EP | disclosed |