Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.57 |
| ▸ | USP2 | O75604 | 1/20 | 0.57 |
| ▸ | NPC1 | O15118 | 7/20 | 0.51 |
| ▸ | RAB9A | P51151 | 7/20 | 0.51 |
| ▸ | LMNA | P02545 | 2/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | TSHR | P16473 | 2/20 | 0.49 |
| ▸ | RECQL | P46063 | 1/20 | 0.49 |
| ▸ | POLB | P06746 | 2/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.48 |
| ▸ | PKM | P14618 | 1/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.47 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.47 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.47 |
| ▸ | RELA | Q04206 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12089187 | 0.87 | SMN1; SMN2 (0.65) | SMN1; SMN2USP2NPC1RAB9ALMNA | |
| SCHEMBL14685205 | 0.80 | SMN1; SMN2 (0.68) | SMN1; SMN2USP2NPC1RAB9ALMNA | |
| SCHEMBL5610013 | 0.80 | SMN1; SMN2 (0.68) | SMN1; SMN2USP2NPC1RAB9ALMNA | |
| SCHEMBL3746825 | 0.78 | SMN1; SMN2 (0.65) | SMN1; SMN2USP2NPC1RAB9ALMNA | |
| SCHEMBL31248989 | 0.78 | SMN1; SMN2 (0.65) | SMN1; SMN2USP2NPC1RAB9ALMNA | |
| SCHEMBL9697539 | 0.77 | SMN1; SMN2 (0.45) | SMN1; SMN2USP2NPC1RAB9ALMNA | |
| SCHEMBL9695968 | 0.76 | SMN1; SMN2 (0.56) | SMN1; SMN2USP2NPC1RAB9ALMNA | |
| SCHEMBL1059693 | 0.76 | RAB9A (0.64) | SMN1; SMN2USP2NPC1RAB9ALMNA | |
| SCHEMBL11995138 | 0.75 | SMN1; SMN2 (0.61) | SMN1; SMN2USP2NPC1RAB9ALMNA | |
| SCHEMBL5608402 | 0.75 | SMN1; SMN2 (0.61) | SMN1; SMN2USP2NPC1RAB9ALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5149700-A | Antiarrhythmic agent | AMERICAN HOME PRODUCTS CORPORATION (US) | 1992-09-22 | — | — | US | disclosed |
| WO-1991018904-A1 | SUBSTITUTED ARYLSULFONAMIDES AND BENZAMIDES | AMERICAN HOME PRODUCTS CORPORATION (US) | 1991-12-12 | — | — | WO | disclosed |