Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.63 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.63 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.63 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.63 |
| ▸ | BCHE | P06276 | 3/20 | 0.53 |
| ▸ | ACHE | P22303 | 1/20 | 0.53 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | NPC1 | O15118 | 2/20 | 0.46 |
| ▸ | RAB9A | P51151 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | PKM | P14618 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 2/20 | 0.43 |
| ▸ | IDO1 | P14902 | 1/20 | 0.43 |
| ▸ | DDAH1 | O94760 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14752596 | 0.89 | CYP1A2 (0.55) | LMNACYP1A2CYP2D6CYP2C19BCHE | |
| SCHEMBL17329336 | 0.83 | BCHE (0.57) | LMNACYP1A2CYP2D6CYP2C19BCHE | |
| SCHEMBL6957354 | 0.83 | LMNA (0.63) | LMNACYP1A2CYP2D6CYP2C19BCHE | |
| SCHEMBL6955715 | 0.79 | LMNA (0.96) | LMNACYP1A2CYP2D6CYP2C19BCHE | |
| SCHEMBL20677817 | 0.78 | BCHE (0.73) | LMNACYP1A2CYP2D6CYP2C19BCHE | |
| SCHEMBL8516354 | 0.76 | LMNA (0.51) | LMNACYP1A2CYP2D6CYP2C19BCHE | |
| SCHEMBL2673648 | 0.76 | LMNA (0.63) | LMNACYP1A2CYP2D6CYP2C19BCHE | |
| SCHEMBL22227972 | 0.75 | LMNA (0.61) | LMNACYP1A2CYP2D6CYP2C19BCHE | |
| SCHEMBL5181863 | 0.73 | BCHE (0.81) | CYP1A2CYP2D6CYP2C19BCHEEPHX2 | |
| SCHEMBL8201331 | 0.72 | BCHE (0.79) | CYP1A2CYP2D6CYP2C19BCHEEPHX2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5149700-A | Antiarrhythmic agent | AMERICAN HOME PRODUCTS CORPORATION (US) | 1992-09-22 | — | — | US | disclosed |
| WO-1991018904-A1 | SUBSTITUTED ARYLSULFONAMIDES AND BENZAMIDES | AMERICAN HOME PRODUCTS CORPORATION (US) | 1991-12-12 | — | — | WO | disclosed |