Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FOLH1 | Q04609 | 5/20 | 0.65 |
| ▸ | GRM3 | Q14832 | 2/20 | 0.50 |
| ▸ | NAALAD2 | Q9Y3Q0 | 1/20 | 0.50 |
| ▸ | ANPEP | P15144 | 1/20 | 0.47 |
| ▸ | LAP3 | P28838 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7605053 | 0.90 | FOLH1 (0.62) | FOLH1GRM3NAALAD2ANPEPLAP3 | |
| SCHEMBL9697381 | 0.85 | SLC1A2 (0.53) | FOLH1ANPEPLAP3 | |
| SCHEMBL9697300 | 0.84 | ANPEP (0.47) | FOLH1GRM3ANPEPLAP3 | |
| SCHEMBL9697329 | 0.83 | GRIK1 (0.55) | ANPEPLAP3 | |
| SCHEMBL9715079 | 0.81 | CHRM1 (0.52) | FOLH1GRM3NAALAD2ANPEPLAP3 | |
| SCHEMBL5060661 | 0.81 | FOLH1 (0.76) | FOLH1GRM3NAALAD2 | |
| SCHEMBL9696208 | 0.80 | FOLH1 (0.60) | FOLH1GRM3ANPEPLAP3 | |
| SCHEMBL12145031 | 0.79 | FOLH1 (1.00) | FOLH1GRM3NAALAD2 | |
| SCHEMBL9697359 | 0.79 | ANPEP (0.56) | ANPEPLAP3 | |
| SCHEMBL9697234 | 0.77 | ERAP1 (0.59) | ANPEPLAP3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5143908-A | Carboxylic acids containing amino and phosphinyl groups | MERCK & CO., INC. (US) | 1992-09-01 | — | — | US | disclosed |
| US-5099063-A | 3-(1-aminoalkylphosphinyl)-(2-substituted)propionic acids | MERCK & CO., INC. (US) | 1992-03-24 | — | — | US | disclosed |
| EP-0266978-A2 | Novel antibacterial agents and potentiators of carbapenem antibiotics | MERCK & CO. INC. (US) | 1988-05-11 | — | — | EP | disclosed |
| US-4715994-A | PHOSPHINIC ACID DERIVATIVES | MERCK & CO., INC. (US) | 1987-12-29 | — | — | US | disclosed |