SCHEMBL9696232

SCHEMBL9696232

ClCSCc1cccnc1

nearest known ligand 0.50

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
CYP1A2 P05177 2/20 0.48
CYP2D6 P10635 2/20 0.48
CHRNA7 P36544 2/20 0.47
ALDH1A1 P00352 1/20 0.46
CHRNB2 P17787 3/20 0.46
CHRNA4 P43681 3/20 0.46
HRH4 Q9H3N8 1/20 0.44
HRH3 Q9Y5N1 1/20 0.44
CYP2A6 P11509 1/20 0.44
NAPRT Q6XQN6 1/20 0.44
HTT P42858 1/20 0.44
SMN1; SMN2 Q16637 1/20 0.44
CYP3A4 P08684 1/20 0.43
CYP2C9 P11712 1/20 0.43
CYP2C19 P33261 1/20 0.43
RECQL P46063 1/20 0.43
DAO P14920 1/20 0.43
TDP1 Q9NUW8 1/20 0.43
L3MBTL1 Q9Y468 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7405579 0.87 CYP1A2 (0.56) CYP1A2CYP2D6CHRNA7ALDH1A1CHRNB2
SCHEMBL11177988 0.82 CHRM2 (0.47) CYP1A2CYP2D6CHRNA7CHRNB2CHRNA4
SCHEMBL30732355 0.82 CYP1A2 (0.50) CYP1A2CYP2D6CHRNA7CHRNB2CHRNA4
SCHEMBL29152282 0.82 CYP1A2 (0.50) CYP1A2CYP2D6CHRNA7CHRNB2CHRNA4
SCHEMBL11179366 0.80 CHRM2 (0.42) CYP1A2CYP2D6CHRNA7CHRNB2CHRNA4
SCHEMBL7750593 0.80 CYP1A2 (0.48) CYP1A2CYP2D6CHRNA7ALDH1A1CHRNB2
SCHEMBL12854012 0.80 CHRNB2 (0.52) CYP1A2CYP2D6CHRNA7ALDH1A1CHRNB2
SCHEMBL3419445 0.79 CYP1A2 (0.56) CYP1A2CYP2D6CHRNA7ALDH1A1CHRNB2
SCHEMBL22922294 0.77 CHRM2 (0.46) CYP1A2CYP2D6CHRNA7CHRNB2CHRNA4
SCHEMBL9267237 0.77 NAPRT (0.46) CYP1A2CYP2D6CHRNA7ALDH1A1CHRNB2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5116833-A ANTIBIOTIC C-3 DITHIOACETAL-SUBSTITUTED CARBAPENEM COMPOUNDS, COMPOSITIONS, AND METHODS OF USE THEREOF BRISTOL-MYERS SQUIBB COMPANY (US) 1992-05-26 US disclosed
EP-0481511-A2 Antibiotic C-3 dithioacetal-substituted carbapenem compounds, compositions, and use thereof Bristol-Myers Squibb Company (US) 1992-04-22 EP disclosed