Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP19A1 | P11511 | 6/20 | 0.62 |
| ▸ | SMPD1 | P17405 | 1/20 | 0.54 |
| ▸ | CYSLTR2 | Q9NS75 | 1/20 | 0.54 |
| ▸ | CYSLTR1 | Q9Y271 | 1/20 | 0.54 |
| ▸ | CNR1 | P21554 | 1/20 | 0.47 |
| ▸ | ACHE | P22303 | 1/20 | 0.47 |
| ▸ | CNR2 | P34972 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | THRA | P10827 | 1/20 | 0.46 |
| ▸ | THRB | P10828 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 2/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9699836 | 1.00 | CYP19A1 (0.62) | CYP19A1SMPD1CYSLTR2CYSLTR1CNR1 | |
| SCHEMBL29163212 | 1.00 | CYP19A1 (0.62) | CYP19A1SMPD1CYSLTR2CYSLTR1CNR1 | |
| SCHEMBL7695074 | 0.99 | CYP19A1 (0.60) | CYP19A1SMPD1CYSLTR2CYSLTR1CNR1 | |
| SCHEMBL5151538 | 0.94 | CYP19A1 (0.54) | CYP19A1SMPD1CYSLTR2CYSLTR1LMNA | |
| SCHEMBL4233734 | 0.90 | CYP19A1 (0.59) | CYP19A1LMNAMAPTNPSR1ALDH1A1 | |
| SCHEMBL9699858 | 0.89 | CYP19A1 (0.58) | CYP19A1CYSLTR2CYSLTR1CNR1ACHE | |
| SCHEMBL27719953 | 0.89 | CYP19A1 (0.58) | CYP19A1CYSLTR2CYSLTR1CNR1ACHE | |
| SCHEMBL9165752 | 0.87 | CYP19A1 (0.66) | CYP19A1CYSLTR2CYSLTR1CNR1ACHE | |
| SCHEMBL30292299 | 0.87 | CYP19A1 (0.66) | CYP19A1CYSLTR2CYSLTR1CNR1ACHE | |
| SCHEMBL9127581 | 0.87 | CYP19A1 (0.66) | CYP19A1CYSLTR2CYSLTR1CNR1ACHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5147864-A | Bronchodilator agent, antianaphylactic agent, antishock agent, cardiotonic agent and anticarcinogenic agent | AMERICAN CYANAMID COMPANY (US) | 1992-09-15 | — | — | US | disclosed |
| US-4983592-A | Bis-arylphosphate ester antagonists of platelet activating factor | AMERICAN CYANAMID CO. (US) | 1991-01-08 | — | — | US | disclosed |
| EP-0374513-A2 | Novel bis-arylphosphate ester antagonists of platelet activating factor | AMERICAN CYANAMID COMPANY (US) | 1990-06-27 | — | — | EP | disclosed |