Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMPD1 | P17405 | 5/20 | 0.59 |
| ▸ | CNR2 | P34972 | 2/20 | 0.55 |
| ▸ | NR5A1 | Q13285 | 1/20 | 0.54 |
| ▸ | ALOX5 | P09917 | 3/20 | 0.50 |
| ▸ | PTGS2 | P35354 | 3/20 | 0.50 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.50 |
| ▸ | CYSLTR2 | Q9NS75 | 1/20 | 0.49 |
| ▸ | CYSLTR1 | Q9Y271 | 1/20 | 0.49 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.49 |
| ▸ | THRA | P10827 | 1/20 | 0.48 |
| ▸ | THRB | P10828 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17534098 | 0.88 | CHRNB4 (0.52) | SMPD1CNR2PDE4B | |
| SCHEMBL11329254 | 0.83 | SMPD1 (0.60) | SMPD1CNR2NR5A1ALOX5CYSLTR2 | |
| SCHEMBL28095186 | 0.83 | NR5A1 (0.58) | SMPD1CNR2NR5A1ALOX5CYSLTR2 | |
| SCHEMBL8974027 | 0.83 | SMPD1 (0.58) | SMPD1PDE4BPRSS1 | |
| SCHEMBL3915123 | 0.83 | CHRNB4 (0.50) | SMPD1CNR2PRSS1 | |
| SCHEMBL14557522 | 0.83 | SMPD1 (0.60) | SMPD1CNR2NR5A1ALOX5CYSLTR2 | |
| SCHEMBL9699080 | 0.81 | ESR1 (0.61) | CNR2NR5A1ALOX5CYSLTR2CYSLTR1 | |
| SCHEMBL9699688 | 0.81 | ESR1 (0.61) | CNR2NR5A1ALOX5CYSLTR2CYSLTR1 | |
| SCHEMBL17445869 | 0.81 | NR5A1 (0.56) | CNR2NR5A1ALOX5CYSLTR2CYSLTR1 | |
| SCHEMBL9697402 | 0.81 | ESR1 (0.61) | CNR2NR5A1ALOX5CYSLTR2CYSLTR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5147864-A | Bronchodilator agent, antianaphylactic agent, antishock agent, cardiotonic agent and anticarcinogenic agent | AMERICAN CYANAMID COMPANY (US) | 1992-09-15 | — | — | US | disclosed |
| US-4983592-A | Bis-arylphosphate ester antagonists of platelet activating factor | AMERICAN CYANAMID CO. (US) | 1991-01-08 | — | — | US | disclosed |
| EP-0374513-A2 | Novel bis-arylphosphate ester antagonists of platelet activating factor | AMERICAN CYANAMID COMPANY (US) | 1990-06-27 | — | — | EP | disclosed |