Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMPD1 | P17405 | 6/20 | 0.73 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.59 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.56 |
| ▸ | POLB | P06746 | 1/20 | 0.56 |
| ▸ | MGLL | Q99685 | 3/20 | 0.53 |
| ▸ | CA12 | O43570 | 1/20 | 0.53 |
| ▸ | CA1 | P00915 | 1/20 | 0.53 |
| ▸ | CA2 | P00918 | 1/20 | 0.53 |
| ▸ | CA7 | P43166 | 1/20 | 0.53 |
| ▸ | XDH | P47989 | 1/20 | 0.53 |
| ▸ | CA9 | Q16790 | 1/20 | 0.53 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.53 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.51 |
| ▸ | THRA | P10827 | 1/20 | 0.49 |
| ▸ | THRB | P10828 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9699106 | 1.00 | SMPD1 (0.73) | SMPD1HDAC6KDM4EPOLBMGLL | |
| SCHEMBL26480881 | 0.94 | SMPD1 (0.64) | SMPD1HDAC6KDM4EPOLBMGLL | |
| SCHEMBL18031232 | 0.90 | KDM4E (0.64) | SMPD1HDAC6KDM4EPOLBCA12 | |
| SCHEMBL9699845 | 0.89 | SMPD1 (0.58) | SMPD1MGLLCA12CA1CA2 | |
| SCHEMBL24950547 | 0.88 | SMPD1 (0.67) | SMPD1MGLLTHRATHRB | |
| SCHEMBL9304902 | 0.88 | SMPD1 (0.67) | SMPD1MGLLTHRATHRB | |
| SCHEMBL967401 | 0.88 | SMPD1 (0.67) | SMPD1MGLLTHRATHRB | |
| SCHEMBL9565566 | 0.88 | SMPD1 (0.67) | SMPD1MGLLTHRATHRB | |
| SCHEMBL28606187 | 0.87 | SMPD1 (0.56) | SMPD1MGLLCA12CA1CA2 | |
| SCHEMBL7335792 | 0.87 | SMPD1 (0.64) | SMPD1MGLLTHRATHRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5147864-A | Bronchodilator agent, antianaphylactic agent, antishock agent, cardiotonic agent and anticarcinogenic agent | AMERICAN CYANAMID COMPANY (US) | 1992-09-15 | — | — | US | disclosed |
| US-4983592-A | Bis-arylphosphate ester antagonists of platelet activating factor | AMERICAN CYANAMID CO. (US) | 1991-01-08 | — | — | US | disclosed |
| EP-0374513-A2 | Novel bis-arylphosphate ester antagonists of platelet activating factor | AMERICAN CYANAMID COMPANY (US) | 1990-06-27 | — | — | EP | disclosed |