Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 20/20 | 0.74 |
| ▸ | PDE1A | P54750 | 4/20 | 0.74 |
| ▸ | PDE1B | Q01064 | 4/20 | 0.74 |
| ▸ | PDE1C | Q14123 | 4/20 | 0.74 |
| ▸ | PDE3B | Q13370 | 3/20 | 0.74 |
| ▸ | PDE3A | Q14432 | 3/20 | 0.74 |
| ▸ | ABCC4 | O15439 | 2/20 | 0.74 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.74 |
| ▸ | PDE2A | O00408 | 1/20 | 0.74 |
| ▸ | ABCC5 | O15440 | 1/20 | 0.74 |
| ▸ | PDE6D | O43924 | 1/20 | 0.74 |
| ▸ | PDE8A | O60658 | 1/20 | 0.74 |
| ▸ | PDE9A | O76083 | 1/20 | 0.74 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.74 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.74 |
| ▸ | HTR1A | P08908 | 1/20 | 0.74 |
| ▸ | PDE6A | P16499 | 1/20 | 0.74 |
| ▸ | PDE6G | P18545 | 1/20 | 0.74 |
| ▸ | PDE4A | P27815 | 1/20 | 0.74 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.74 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3671938 | 0.87 | PDE5A (0.63) | PDE5APDE1APDE1BPDE1CPDE3B | |
| SCHEMBL31155720 | 0.87 | PDE5A (0.71) | PDE5APDE1APDE1BPDE1CPDE3B | |
| SCHEMBL3671939 | 0.85 | PDE5A (0.55) | PDE5APDE1APDE1BPDE1CPDE3B | |
| Sildenafil SCHEMBL5683880 | 0.85 | PDE5A (1.00) | PDE5APDE1APDE1BPDE1CPDE3B | |
| Sildenafil SCHEMBL1895 | 0.85 | PDE5A (1.00) | PDE5APDE1APDE1BPDE1CPDE3B | |
| Sildenafil SCHEMBL29361663 | 0.85 | PDE5A (1.00) | PDE5APDE1APDE1BPDE1CPDE3B | |
| Sildenafil SCHEMBL5691322 | 0.85 | PDE5A (0.98) | PDE5APDE1APDE1BPDE1CPDE3B | |
| Sildenafil SCHEMBL19410952 | 0.85 | PDE5A (0.98) | PDE5APDE1APDE1BPDE1CPDE3B | |
| Sildenafil SCHEMBL584340 | 0.85 | PDE5A (0.98) | PDE5APDE1APDE1BPDE1CPDE3B | |
| Sildenafil SCHEMBL7915871 | 0.85 | PDE5A (0.98) | PDE5APDE1APDE1BPDE1CPDE3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111732593-A | Piperazine oxide derivative and composition, preparation method and application thereof | 黄泳华 | 2020-10-02 | — | — | CN | claimed |
| JP-11171879-A | — | — | None | — | — | JP | disclosed |
| CN-111732593-A | Piperazine oxide derivative and composition, preparation method and application thereof | 黄泳华 | 2020-10-02 | — | — | CN | disclosed |
| US-6200980-B1 | ADMINISTERING PHENYL PURINONE COMPOUND FOR TREATING PRECANCEROUS LEISONS | CELL PATHWAYS, INC. | 2001-03-13 | — | — | US | disclosed |
| JP-H11171879-A | PRODUCTION OF SILDENAFIL | PFIZER INC | 1999-06-29 | — | — | JP | disclosed |
| EP-0463756-B1 | Pyrazolopyrimidinone antianginal agents | PFIZER LTD (GB) | 1995-04-19 | — | — | EP | disclosed |
| US-5346901-A | Treatment of angina, hypertension, heart failure and atherosclerosis | PFIZER INC. (US) | 1994-09-13 | — | — | US | disclosed |
| US-5250534-A | Inhibitors of cyclic guanosine 3*,5*-monophosphate phosphodiesterase | PFIZER INC. (US) | 1993-10-05 | — | — | US | disclosed |
| EP-0463756-A1 | Pyrazolopyrimidinone antianginal agents | Pfizer Limited (GB) | 1992-01-02 | — | — | EP | disclosed |