Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 19/20 | 0.63 |
| ▸ | PDE3B | Q13370 | 4/20 | 0.63 |
| ▸ | PDE3A | Q14432 | 4/20 | 0.63 |
| ▸ | PDE1A | P54750 | 3/20 | 0.63 |
| ▸ | PDE1B | Q01064 | 3/20 | 0.63 |
| ▸ | PDE1C | Q14123 | 3/20 | 0.63 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.63 |
| ▸ | PDE2A | O00408 | 1/20 | 0.63 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.63 |
| ▸ | ABCC5 | O15440 | 1/20 | 0.63 |
| ▸ | PDE6D | O43924 | 1/20 | 0.63 |
| ▸ | PDE8A | O60658 | 1/20 | 0.63 |
| ▸ | PDE9A | O76083 | 1/20 | 0.63 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.63 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.63 |
| ▸ | HTR1A | P08908 | 1/20 | 0.63 |
| ▸ | PDE6A | P16499 | 1/20 | 0.63 |
| ▸ | PDE6G | P18545 | 1/20 | 0.63 |
| ▸ | PDE4A | P27815 | 1/20 | 0.63 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.63 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7778185 | 0.92 | PDE5A (0.54) | PDE5APDE3BPDE3APDE1APDE1B | |
| SCHEMBL4653199 | 0.91 | PDE5A (0.53) | PDE5APDE3BPDE3APDE1APDE1B | |
| Citric Acid SCHEMBL18919600 | 0.91 | PDE5A (0.68) | PDE5APDE3BPDE3APDE1APDE1B | |
| SCHEMBL1906070 | 0.87 | PDE5A (0.60) | PDE5APDE3BPDE3APDE1APDE1B | |
| SCHEMBL970 | 0.87 | PDE5A (0.74) | PDE5APDE3BPDE3APDE1APDE1B | |
| SCHEMBL7019550 | 0.82 | PDE5A (0.46) | PDE5APDE3BPDE3APDE1APDE1B | |
| SCHEMBL7362346 | 0.81 | PDE5A (0.43) | PDE5APDE3BPDE3APDE1APDE1B | |
| SCHEMBL14685954 | 0.81 | KDM4E (0.48) | PDE5APDE3BPDE3APDE1APDE2A | |
| SCHEMBL3671939 | 0.79 | PDE5A (0.55) | PDE5APDE3BPDE3APDE1APDE1B | |
| SCHEMBL14685941 | 0.78 | KDM4E (0.46) | PDE5APDE1APDE2AABCC5PDE9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2556820-A2 | COMPOSITION CONTAINING PDE5 INHIBITOR FOR RELIEVING SKIN WRINKLES | SK Chemicals, Co., Ltd. (KR) | 2013-02-13 | — | — | EP | claimed |
| WO-2013067309-A1 | METHODS AND COMPOSITIONS FOR ORAL ADMINISTRATION OF MELANOCORTIN RECEPTOR AGONIST COMPOUNDS | XION PHARMACEUTICAL CORPORATION (US) | 2013-05-10 | — | — | WO | disclosed |
| EP-2556820-A2 | COMPOSITION CONTAINING PDE5 INHIBITOR FOR RELIEVING SKIN WRINKLES | SK Chemicals, Co., Ltd. (KR) | 2013-02-13 | — | — | EP | disclosed |
| EP-2240467-A1 | AMIDE DERIVATIVES AS ION-CHANNEL LIGANDS AND PHARMACEUTICAL COMPOSITIONS AND METHODS OF USING THE SAME | Renovis, Inc. (US) | 2010-10-20 | — | — | EP | disclosed |
| WO-2009089057-A1 | AMIDE DERIVATIVES AS ION-CHANNEL LIGANDS AND PHARMACEUTICAL COMPOSITIONS AND METHODS OF USING THE SAME | RENOVIS, INS. (US) | 2009-07-16 | — | — | WO | disclosed |
| EP-2024272-A2 | AMIDE DERIVATIVES AS ION-CHANNEL LIGANDS AND PHARMACEUTICAL COMPOSITIONS AND METHODS OF USING THE SAME | Renovis, Inc. (US) | 2009-02-18 | — | — | EP | disclosed |
| EP-1868590-A2 | METHOD OF INCREASING TESTOSTERONE AND RELATED STEROID CONCENTRATIONS IN WOMEN | Unimed Pharmaceuticals, Inc. (US) | 2007-12-26 | — | — | EP | disclosed |
| WO-2007133637-A2 | AMIDE DERIVATIVES AS ION-CHANNEL LIGANDS AND PHARMACEUTICAL COMPOSITIONS AND METHODS OF USING THE SAME | RENOVIS, INC. (US) | 2007-11-22 | — | — | WO | disclosed |
| WO-2006113242-A2 | METHOD OF INCREASING TESTOSTERONE AND RELATED STEROID CONCENTRATIONS IN WOMEN | UNIMED PHARMACEUTICALS, INC. (US) | 2006-10-26 | — | — | WO | disclosed |