Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Crotonic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 4/20 | 0.53 |
| ▸ | TP53 | P04637 | 1/20 | 0.53 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.53 |
| ▸ | EGLN3 | Q9H6Z9 | 1/20 | 0.53 |
| ▸ | HCAR2 | Q8TDS4 | 4/20 | 0.41 |
| ▸ | GABRP | O00591 | 2/20 | 0.39 |
| ▸ | GABRD | O14764 | 2/20 | 0.39 |
| ▸ | GABRA1 | P14867 | 2/20 | 0.39 |
| ▸ | GABRB1 | P18505 | 2/20 | 0.39 |
| ▸ | GABRG2 | P18507 | 2/20 | 0.39 |
| ▸ | GABRB3 | P28472 | 2/20 | 0.39 |
| ▸ | GABRA5 | P31644 | 2/20 | 0.39 |
| ▸ | GABRA3 | P34903 | 2/20 | 0.39 |
| ▸ | GABRA2 | P47869 | 2/20 | 0.39 |
| ▸ | GABRB2 | P47870 | 2/20 | 0.39 |
| ▸ | GABRA4 | P48169 | 2/20 | 0.39 |
| ▸ | GABRE | P78334 | 2/20 | 0.39 |
| ▸ | GABRA6 | Q16445 | 2/20 | 0.39 |
| ▸ | GABRG1 | Q8N1C3 | 2/20 | 0.39 |
| ▸ | GABRG3 | Q99928 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Crotonic Acid SCHEMBL9699990 | 1.00 | TSHR (0.53) | TSHRTP53EGLN1EGLN3HCAR2 | |
| Crotonic Acid SCHEMBL1080122 | 0.96 | TSHR (0.57) | TSHRTP53EGLN1EGLN3HCAR2 | |
| Crotonic Acid SCHEMBL1428157 | 0.96 | TSHR (0.57) | TSHRTP53EGLN1EGLN3HCAR2 | |
| Crotonic Acid SCHEMBL167626 | 0.96 | TSHR (0.57) | TSHRTP53EGLN1EGLN3HCAR2 | |
| Crotonic Acid SCHEMBL1427547 | 0.96 | TSHR (0.57) | TSHRTP53EGLN1EGLN3HCAR2 | |
| Crotonic Acid SCHEMBL28429 | 0.96 | — | — | |
| Crotonic Acid SCHEMBL560763 | 0.96 | TSHR (0.57) | TSHRTP53EGLN1EGLN3HCAR2 | |
| Crotonic Acid SCHEMBL22033 | 0.96 | — | — | |
| Crotonic Acid SCHEMBL22034 | 0.96 | — | — | |
| Crotonic Acid SCHEMBL28100211 | 0.94 | TSHR (0.47) | TSHRTP53EGLN1EGLN3HCAR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111247681-B | Electrolyte, electrochemical device, lithium ion secondary battery and assembly | 大金工业株式会社 | 2023-07-14 | — | — | CN | disclosed |
| CN-116154292-A | Electrolyte, electrochemical device, lithium ion secondary battery and assembly | 大金工业株式会社 | 2023-05-23 | — | — | CN | disclosed |
| CN-116057036-A | Fluorine-containing carboxylate compound | 大金工业株式会社 | 2023-05-02 | — | — | CN | disclosed |
| US-5140052-A | Using a tertiary amine as a dicarbonate decomposition catalyst along with water as a promoter in foam-producing systems at environmental temperatures | AKZO N.V. (NL) | 1992-08-18 | — | — | US | disclosed |
| US-5030664-A | Combining with a tertiary amine decomposition catalyst to produce carbon dioxide in polyurethanes | AKZO N.V. (NL) | 1991-07-09 | — | — | US | disclosed |