Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TGFBR1 | P36897 | 3/20 | 0.42 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 4/20 | 0.38 |
| ▸ | RAB9A | P51151 | 4/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.38 |
| ▸ | TP53 | P04637 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.35 |
| ▸ | HTT | P42858 | 3/20 | 0.35 |
| ▸ | THRB | P10828 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.34 |
| ▸ | MAPT | P10636 | 3/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.34 |
| ▸ | CASP3 | P42574 | 1/20 | 0.34 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.34 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.34 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.34 |
| ▸ | CSNK1D | P48730 | 2/20 | 0.33 |
| ▸ | CSNK1E | P49674 | 2/20 | 0.33 |
| ▸ | PKM | P14618 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9198377 | 0.79 | PDE10A (0.45) | TGFBR1PDE10ANPC1RAB9AKDM4E | |
| SCHEMBL9204502 | 0.76 | PDE10A (0.43) | TGFBR1PDE10ANPC1RAB9AKDM4E | |
| SCHEMBL9700052 | 0.76 | PDE10A (0.47) | TGFBR1PDE10ANPC1RAB9AKDM4E | |
| SCHEMBL9698891 | 0.76 | POLB (0.44) | TGFBR1PDE10ANPC1RAB9AKDM4E | |
| SCHEMBL7352500 | 0.74 | PDE10A (0.51) | TGFBR1PDE10ANPC1RAB9AKDM4E | |
| SCHEMBL9752587 | 0.74 | PDE10A (0.60) | TGFBR1PDE10ANPC1RAB9AKDM4E | |
| SCHEMBL9524943 | 0.72 | TGFBR1 (0.46) | TGFBR1PDE10ANPC1RAB9AKDM4E | |
| SCHEMBL7376928 | 0.72 | PDE10A (0.46) | TGFBR1PDE10ANPC1RAB9AKDM4E | |
| SCHEMBL9700065 | 0.72 | PDE10A (0.44) | TGFBR1PDE10ANPC1RAB9AKDM4E | |
| SCHEMBL9700106 | 0.71 | PDE10A (0.47) | TGFBR1PDE10ANPC1RAB9AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5145858-A | Antiinflammatory | SMITHKLINE BEECHAM CORP. (US) | 1992-09-08 | — | — | US | disclosed |
| US-5002941-A | Antiarthritic agents, arachidonic acid metabolism | SMITHKLINE BEECHAM CORPORATION (US) | 1991-03-26 | — | — | US | disclosed |
| WO-1990003789-A1 | PYRROLO[1,2-a]IMIDAZOLE AND IMIDAZO[1,2-a]PYRIDINE DERIVATIVES AND THEIR USE AS 5-LYPOXYGENASE PATHWAY INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 1990-04-19 | — | — | WO | disclosed |
| EP-0364204-A1 | Pyrrolo[1,2-a]imidazole and imidazo[1,2-a]pyridine derivatives and their use as 5-lipoxygenase pathway inhibitors | SMITHKLINE BEECHAM CORPORATION (US) | 1990-04-18 | — | — | EP | disclosed |